The role of glucokinase in glucose homeostasis and its potential therapeutic target in type 2 diabetes

Other Title(s)

دور الجلوكوكيناز في توازن الجلوكوز و هدفه العلاجي المحتمل في مرض السكري من النوع الثاني

Author

Ali, Nada Mahmud

Source

Journal of the North for Basic and Applied Sciences

Issue

Vol. 7, Issue 1 (31 May. 2022), pp.55-69, 15 p.

Publisher

Northern Border University Scientific Publishing Center

Publication Date

2022-05-31

Country of Publication

Saudi Arabia

No. of Pages

15

Main Subjects

Chemistry

Abstract EN

Type 2 diabetes (T2D) is characterized by increased resistance of tissues to insulin that disrupts body-wise glucose homeostasis.

Insulin is one of the critical harmonic regulators of glucose homeostasis.

The release of insulin from pancreatic P-cells is dependent on the enzyme glucokinase (GK) involved in glycolysis and ATP production required for membrane depolarization and insulin release from secretory granules.

Identification of these molecular pathways and their association with the pathogenesis of T2D, has given rise to new methods of disease modulation and limiting its progression by targeting the critical enzymes involved in mediating glycolytic flux.

This article provides an overview of the role of GK in glucose homeostasis and its regulation by various factors in the treatment of T2D.

Data used for this review was based on a search from several science databases.

The primary data search terms used were glucokinase, glucose homeostasis, type 2 diabetes and glucokinase regulation.

GK acts as a sensor of glucose levels in pancreatic P-cells and as a glucose “gatekeeper” in hepatocytes.

Its dual roles (enhancing influx of glucose in hepatocytes and insulin release in the pancreas) play a crucial role in bringing down blood glucose levels to normal.

This makes GK and its pharmacological activation via glucokinase activators (GKA) and inducers a potential target for treating T2D and inhibiting disease progression.

American Psychological Association (APA)

Ali, Nada Mahmud. 2022. The role of glucokinase in glucose homeostasis and its potential therapeutic target in type 2 diabetes. Journal of the North for Basic and Applied Sciences،Vol. 7, no. 1, pp.55-69.
https://search.emarefa.net/detail/BIM-1425982

Modern Language Association (MLA)

Ali, Nada Mahmud. The role of glucokinase in glucose homeostasis and its potential therapeutic target in type 2 diabetes. Journal of the North for Basic and Applied Sciences Vol. 7, no. 1 (May. 2022), pp.55-69.
https://search.emarefa.net/detail/BIM-1425982

American Medical Association (AMA)

Ali, Nada Mahmud. The role of glucokinase in glucose homeostasis and its potential therapeutic target in type 2 diabetes. Journal of the North for Basic and Applied Sciences. 2022. Vol. 7, no. 1, pp.55-69.
https://search.emarefa.net/detail/BIM-1425982

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 64-69

Record ID

BIM-1425982