
Developing and evaluating of microemulsion systems for potential transdermal application of omeprazole
Other Title(s)
تطوير و تقييم نظم إيصال دواء غروية للتطبيق عبر الجلد للأوميبرازول
Dissertant
Thesis advisor
al-Karad, Jamal al-Yusuf
Hassunah, Luayy
University
Isra University
Faculty
Faculty of Pharmacy
University Country
Jordan
Degree
Master
Degree Date
2022
English Abstract
Omeprazole is the first of a class of medications that inhibit gastric secretion by changing the activity of H+ / K+ -ATPase in the gastric parietal cells, which is the final stage in acid secretion.
It is currently commercially available in an oral dosage form.
It has a low bioavailability of 30-40% and short half-life.
In this study, non-ionic microemulsions containing omeprazole were produced and characterized for transdermal and intranasal application.
The droplet size, rheological characteristics, poly disparity index, flow through skin, and in vivo bioavailability of the microemulsions were all measured.
Except for one of the created microemulsions, all formulations demonstrated Newtonian viscosity and had droplet size smaller than 200 nm, the skin permeation of microemulsions containing omeprazole through excised rat epidermis showed flux ranging between 9.945 and 0.86 Hg.cm"2h_1.
The in vivo study showed that the intranasal and transdermal percentage relative bioavailability in comparison to an oral solution were 329% and 103 %, respectively.
The produced formulations were stable microemulsions that could serve as good carriers and promising formulations for omeprazole delivery via transdermal and intranasal routes.
Main Subjects
No. of Pages
60
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Introduction.
Chapter Two : Literature review.
Chapter Three : Methodology.
Chapter Four : Results.
Chapter Five : Discussion.
Chapter Six : Conclusion and recommendations.
References.
American Psychological Association (APA)
Husayn, Hibah Hamid. (2022). Developing and evaluating of microemulsion systems for potential transdermal application of omeprazole. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1428799
Modern Language Association (MLA)
Husayn, Hibah Hamid. Developing and evaluating of microemulsion systems for potential transdermal application of omeprazole. (Master's theses Theses and Dissertations Master). Isra University. (2022).
https://search.emarefa.net/detail/BIM-1428799
American Medical Association (AMA)
Husayn, Hibah Hamid. (2022). Developing and evaluating of microemulsion systems for potential transdermal application of omeprazole. (Master's theses Theses and Dissertations Master). Isra University, Jordan
https://search.emarefa.net/detail/BIM-1428799
Language
English
Data Type
Arab Theses
Record ID
BIM-1428799