Iron profile and some hematological parameters among Sudanese patients with rheumatoid arthritis at Khartoum state

Abstract EN

Background Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by the involvement of numerous joints and by systemic symptoms, which leads to disability and premature death, Anemia is the most often hematological manifestation issue that occurs in RA.

Objective: This study aimed to evaluate CBC and to assess iron deficiency in RA Sudanese patients in Khartoum state.

Material and methods: This retrospective observational study was conducted on 63 RA patients and 63 healthy individuals as control between 2018 and 2021.

The CBC and iron profile (serum ferritin, serum iron and total iron binding capacity) were carried out, the Transferrin saturation (TS) was calculated using the formula: TS (%) = [serum iron (ug/dl)/serum transferring (mg/dl)] (Theodoros Eleftheriadis, et al.

2010) Result: In anemic RA patients the MCV, MCH levels, serum iron, serum Ferritin, and TS% were significant decrease while there was a significant increase in platelets count compared to control.

Conclusion: Iron deficiency is common (77%) of anemic RA patients while there was (22%) of ACD.

RA patients had lower serum iron, lower ferritin and lower TS%, while there was increase in platelets count, Decreased hemoglobin was the strongest determinants of iron deficiency.