Risk of hypertension associated with antivascular endothelial growth factor monoclonal antibodies : a meta-analysis from 51088 patients with cancer

Joint Authors

Cai, Le
Wang, Weilan
Xiao, Bingkun
Huang, Rongqing

Source

Iranian Red Crescent Medical Journal

Issue

Vol. 22, Issue 7 (31 Jul. 2020), pp.1-16, 16 p.

Publisher

Iranian Hospital

Publication Date

2020-07-31

Country of Publication

United Arab Emirates

No. of Pages

16

Main Subjects

Medicine

Abstract EN

Context: Hypertension events are the dominant adverse events observed in patients receiving the antivascular endothelial growth factor (anti-VEGF) monoclonal antibodies bevacizumab and ramucirumab treatment, which severe hypertension, particularly hy- pertensive emergencies, may cause acute target organ injury and major cardiovascular events, that has limited the administration of anti-VEGF monoclonal antibodies.

The current meta-analysis aimed to examine the relative risk (RR) of hypertension associated with anti-VEGF monoclonal antibodies.

Evidence Acquisition: PubMed, EMBASE, ASCO Abstracts, ESMO Abstracts, Cochrane Library, and Clinical Trials.gov were searched until July 2019 for relevant phase II and III randomized controlled trials (RCTs).

Statistical analyses were performed to examine the RR (with 95% confidence intervals (CIs)) of hypertension associated with the anti-VEGF monoclonal antibodies.

Results: Ninety four RCTs and 51088 patients were included in the current meta-analysis.

According to the results, compared with the control arms, anti-VEGF monoclonal antibodies increased the risk of all-grade (RR: 3.45, 95% CI: 2.98 - 4.00) and high-grade (RR: 5.63, 95% CI: 5.05 - 6.26) hypertension.

In the subgroup analyses, the risk of high-grade hypertension varied significantly with cancer type, so that the highest RR was for patients with ovarian cancer (17.27, 95% CI: 8.50 - 35.08), whereas the risk of all-grade hypertension did not vary significantly.

When stratified based on drug types and drug dose, no significant difference was discovered.

Conclusions: Anti-VEGF monoclonal antibodies significantly increased the risk of hypertension.

The risk may vary with tumor type.

Clinicians should be aware of the adverse reaction and clinical monitoring as well as effective management of such situations, particularly for high-risk patients.

American Psychological Association (APA)

Wang, Weilan& Cai, Le& Xiao, Bingkun& Huang, Rongqing. 2020. Risk of hypertension associated with antivascular endothelial growth factor monoclonal antibodies : a meta-analysis from 51088 patients with cancer. Iranian Red Crescent Medical Journal،Vol. 22, no. 7, pp.1-16.
https://search.emarefa.net/detail/BIM-1430516

Modern Language Association (MLA)

Wang, Weilan…[et al.]. Risk of hypertension associated with antivascular endothelial growth factor monoclonal antibodies : a meta-analysis from 51088 patients with cancer. Iranian Red Crescent Medical Journal Vol. 22, no. 7 (Jul. 2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1430516

American Medical Association (AMA)

Wang, Weilan& Cai, Le& Xiao, Bingkun& Huang, Rongqing. Risk of hypertension associated with antivascular endothelial growth factor monoclonal antibodies : a meta-analysis from 51088 patients with cancer. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 7, pp.1-16.
https://search.emarefa.net/detail/BIM-1430516

Data Type

Journal Articles

Language

English

Notes

Includes appendix : p. 13-16

Record ID

BIM-1430516