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Correlation of serum homocysteine with attention and executive functions in patients with type I stable bipolar affective disorder
Joint Authors
Na, Wan Qiu
Sun, Ju Shui
Chen, Hai Zhi
Wu, Li Na
Li, Jian Hua
Mei, Li Feng
Su, Wei
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 12 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Publication Date
2020-12-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Abstract EN
Objectives: The current study aimed to examine the correlation of the level of homocysteine (Hcy) in the serum with attention and executive functions in patients suffering from type I stable bipolar affective disorder (BPAD I).
Methods: The present cross-sectional study was conducted on 170 participants in Huzhou, Zhejiang province, China, within July 2016 to December 2017.
The subjects were divided into patients with schizophrenia (n=100) as the study group and healthy volunteers (n=70) as the control group.
The Hcy and folic acid levels of fasting ulnar vein serum were determined using chemiluminescent microparticle immunoassay.
Patient attention was evaluated by the Trail Making Test A (TMTA), and executive functions were assessed using the Trail Making Test B (TMTB) and Stroop Color and Word Test (SCWT).
Results: The mean value of serum Hcy was significantly higher in the study group than that reported for the control group (19.01±5.83 and 11.40±4.62; P<0.001).
The results of several tests of attention (59.39±19.27 and 53.26±14.82; P=0.027) and executive functions (123.75±40.60 and 107.52±29.31; P=0.013) were poorer in the study group.
The serum Hcy value positively correlated with the disturbance variables of the TMTA, TMTB, and Trail Making Test.
However, the duration of the Stroop-C test (SCT) and SCWT negatively correlated with the correct number of the SCT and SCWT.
Conclusions: The increase in the level of serum Hcy closely correlated with the impairment of attention and executive functions in patients suffering from stable BPAD I
American Psychological Association (APA)
Na, Wan Qiu& Su, Wei& Sun, Ju Shui& Chen, Hai Zhi& Wu, Li Na& Li, Jian Hua…[et al.]. 2020. Correlation of serum homocysteine with attention and executive functions in patients with type I stable bipolar affective disorder. Iranian Red Crescent Medical Journal،Vol. 22, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-1430523
Modern Language Association (MLA)
Na, Wan Qiu…[et al.]. Correlation of serum homocysteine with attention and executive functions in patients with type I stable bipolar affective disorder. Iranian Red Crescent Medical Journal Vol. 22, no. 12 (Dec. 2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1430523
American Medical Association (AMA)
Na, Wan Qiu& Su, Wei& Sun, Ju Shui& Chen, Hai Zhi& Wu, Li Na& Li, Jian Hua…[et al.]. Correlation of serum homocysteine with attention and executive functions in patients with type I stable bipolar affective disorder. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 12, pp.1-6.
https://search.emarefa.net/detail/BIM-1430523
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-1430523