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Relationship between Duffy antigen receptor for chemokines and clinical characteristics in Han people with chronic hepatitis c infection in Dalian, China ،
Joint Authors
Liu, Ming
Shao, Lin-Nan
Zhou, Shi-Hang
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 10 (31 Oct. 2020), pp.1-5, 5 p.
Publisher
Publication Date
2020-10-31
Country of Publication
United Arab Emirates
No. of Pages
5
Main Subjects
Abstract EN
Background: Most patients with untreated chronic hepatitis C virus (HCV) infection develop hepatic fibrosis.
Hepatic disease progression is monitored with hematological markers (alanine aminotransferase [ALT], aspartate aminotransferase [AST], albumin and platelet [PLT] count, AST/ALT ratio, AST/PLT ratio index [APRI], and fibrosis 4 score [FIB-4]) and FibroScan (manufactured in Echosens, France).
Objectives: The present study aimed to investigate the association between Duffy antigen/chemokines receptor (DARC) polymorphisms and clinical parameters in the Han people with chronic hepatitis C infection in Dalian, China.
Methods: This cohort study was performed on 245 Han people with chronic HCV at Dalian infectious hospital during April-December 2015.
The participants of the research were selected using the consecutive sampling method.
The DARC genotyping was performed using the TaqMan probe method and transient elastography was measured by FibroScan.
Results: Based on the findings, DARC polymorphisms correlated with ALT concentrations (FY*A/FY*A vs.
FY*A/FY*B, P=0.025).
However, the DARC polymorphism did not have an association with HCV RNA titers (FY*A/FY*A vs.
FY*A/FY*B, P=0.241) or hepatic fibrosis (FY*A/FY*A vs.
FY*A/FY*B, P=0.325).
Moreover, correlation analyses showed that APRI (P<0.001, rho=0.603) and FIB-4 (P<0.001, rho=0.698) were useful predictors of hepatic fibrosis in chronic HCV infection.
Besides, HCV RNA titers (P=0.327) and hepatic injury markers (P=0.814, 0.198, 0.767, and 0.171 for ALT, AST, ALB, and AST/ALT, respectively) were not useful for the estimation of the fibrosis stage in patients with chronic hepatitis C.
Conclusion: The FY*A allele is a potentially valuable protective factor against hepatocyte damage in chronic HCV-infected patients.
American Psychological Association (APA)
Shao, Lin-Nan& Zhou, Shi-Hang& Liu, Ming. 2020. Relationship between Duffy antigen receptor for chemokines and clinical characteristics in Han people with chronic hepatitis c infection in Dalian, China ،. Iranian Red Crescent Medical Journal،Vol. 22, no. 10, pp.1-5.
https://search.emarefa.net/detail/BIM-1430679
Modern Language Association (MLA)
Zhou, Shi-Hang…[et al.]. Relationship between Duffy antigen receptor for chemokines and clinical characteristics in Han people with chronic hepatitis c infection in Dalian, China ،. Iranian Red Crescent Medical Journal Vol. 22, no. 10 (Oct. 2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1430679
American Medical Association (AMA)
Shao, Lin-Nan& Zhou, Shi-Hang& Liu, Ming. Relationship between Duffy antigen receptor for chemokines and clinical characteristics in Han people with chronic hepatitis c infection in Dalian, China ،. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 10, pp.1-5.
https://search.emarefa.net/detail/BIM-1430679
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 4-5
Record ID
BIM-1430679