A rare case of anti-HMGCR and anti-SRP-positive immune-mediated necrotizing myopathy
Joint Authors
Source
Issue
Vol. 2022, Issue 1 (30 Apr. 2022), pp.1-3, 3 p.
Publisher
Publication Date
2022-04-30
Country of Publication
Qatar
No. of Pages
3
Main Subjects
Abstract EN
Immune-mediated necrotizing myopathy (IMNM) or necrotizing autoimmune myopathy includes a set of distinct disorders associated with marked myasthenia, myofiber necrosis, and high creatine kinase levels.
Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (anti-HMGCR) and anti-signal recognition particle (anti-SRP) are the two main autoantibodies associated with IMNM.
Anti-HMGCR is usually associated with statin use.
However, it may also be discovered in children without previous statin exposure, suggesting the existence of a complex genetic–environmental relationship in disease pathogenesis.
Anti-SRP IMNM tends to present with more severe disease distinguished by pronounced myasthenia, worse neurologic outcomes, and treatment refractoriness.
Its pathogenesis is also unknown; however, preliminary data suggest an antibody–complement-mediated mechanism of muscle cell lysis.
Herein, we present the case of a 63-year-old man diagnosed with anti-HMGCR- and anti-SRP-positive IMNM that was treated with multiple immunosuppressants resulting in clinical improvement.
American Psychological Association (APA)
Khan, Nariman& Kazim, Zahrah. 2022. A rare case of anti-HMGCR and anti-SRP-positive immune-mediated necrotizing myopathy. Qatar Medical Journal،Vol. 2022, no. 1, pp.1-3.
https://search.emarefa.net/detail/BIM-1431438
Modern Language Association (MLA)
Khan, Nariman& Kazim, Zahrah. A rare case of anti-HMGCR and anti-SRP-positive immune-mediated necrotizing myopathy. Qatar Medical Journal No. 1 (2022), pp.1-3.
https://search.emarefa.net/detail/BIM-1431438
American Medical Association (AMA)
Khan, Nariman& Kazim, Zahrah. A rare case of anti-HMGCR and anti-SRP-positive immune-mediated necrotizing myopathy. Qatar Medical Journal. 2022. Vol. 2022, no. 1, pp.1-3.
https://search.emarefa.net/detail/BIM-1431438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3
Record ID
BIM-1431438