تقييم الجرعة الشعاعية التراكمية للمرضى المعالجين بالأشعة فوق البنفسجية في مشفى الأمراض الجلدية الجامعي-جامعة دمشق

Abstract EN

Background and aim: Phototherapy using ultraviolet rays is considered a safe and effective treatment in many skin conditions such as mycosis fungoides, psoriasis vulgaris, vitiligo and renal chronic pruritus.

In order to avoid the side effects of ultraviolet radiation, controls have been established for the maximum permissible radiation dose.

Our research aims to assess the radiation dose in patients treated in the Department of Photodynamic Therapy at the University Hospital of Dermatology at the University of Damascus.

Methods: Data of patients with mycosis fungoides and psoriasis vulgaris treated during the period: September 2020 until September 2021, with narrowband ultraviolet type B (NBUVB) were collected from the photodynamic department of the Dermatology Hospital after obtaining the required approvals.The sample size was 18 patients.

The cumulative radiation dose was calculated in (joule/cm2) for patients until stopping treatment as a result of reaching clearance (more than 95% of the skin lesion has disappeared) or directing the patient to receive another treatment.

Using statistical analysis system IBM SPSS v.25.

Results: The study included 14 patients with mycosis fungoides and 4 patients with psoriasis vulgaris, the mean and standard deviation (MEAN±SD) for the number of sessions in the total sample was (87.61 ± 30.01), in the mycosis fungoides group (94.57 ± 30.4) and in the psoriasis vulgaris group (63.25 ± 9.1), and for the cumulative radiation dose in the total sample (83.79 ± 35.14), in the mycosis fungoides group (87.34 ± 35.24) and in the psoriasis group (71.38 ± 36.74) joules/cm2.: Thirteen patients achieved clearance from the complete study group with a percentage of 72.22% with a median cumulative radiation dose of 71.29±29.53 J/cm², while 5 patients were transferred to other treatments with a percentage of 27.78% with an average cumulative dose of 116.298±28.33 J/cm².

These values are similar to international doses and do not exceed the recommendations for safe use.

Conclusion: Patients in the Dermatology Hospital are following the recommendations of safe phototherapy, but close observation is necessary in unresponsive cases to transfer the patient as soon as possible to receive another treatment without waiting for a large number of sessions and receiving a high radiation dose without utility, with the need to adhere to the recommendations for safe use.