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Bacterial coinfections and secondary infections in COVID-19 patients from a tertiary care hospital of northern India : Time to adhere to culture-based practices
Joint Authors
Sharma, Bhawna
Puri, Goverdhan Dutt
Sreenivasan, Priya
Biswal, Manisha
Mahajan, Varun
Suri, Vikas
Sehgal, Inderpaul Singh
Ray, Pallab
Yaddanapud, Lakshmi Narayana
Koushal, Vipin
Angrup, Archana
Bhalla, Ashish
Source
Issue
Vol. 2021, Issue 3 (31 Dec. 2021)
Publisher
Publication Date
2021-12-31
Country of Publication
Qatar
Main Subjects
Abstract EN
Objective: Bacterial co-pathogens are common in various viral respiratory tract infections, leading to increased disease severity and mortality.
Still, they are understudied during large outbreaks and pandemics.
This study was conducted to highlight the overall burden of these infections in COVID-19 patients admitted to our tertiary care hospital, along with their antibiotic susceptibility patterns.
Material and methods: During the six-month study period, clinical samples (blood samples, respiratory samples, and sterile body fluids, including cerebrosp inal fluid [CSF]) of COVID-19 patients with suspected bacterial coinfections (at presentation) or secondary infections (after 48 hours of hospitalization) were received and processed for the same.
Results: Clinical samples of 814 COVID-19 patients were received for bacterial culture and susceptibility.
Out of the total patient sample, 75% had already received empirical antibiotics before the samples were sent for analysis.
Overall, 17.9% of cultures were positive for bacterial infections.
Out of the total patients with bacterial infection, 74% (108/146) of patients had secondary bacterial infections (after 48 hours of hospitalization) and 26% (38/146) had bacterial coinfections (at the time of admission).
Out of the 143 total isolates obtained, the majority (86%) were gram-negative organisms, of which Acinetobacter species was the commonest organism (35.6%), followed by Klebsiella pneumoniae (18.1%).
The majority (50.7%) of the pathogenic organisms reported were multidrug resistant , Conclusion: The overall rate of secondary bacterial infections (SBIs) in our study was lower (7.9%) than reported by other studies.
A rational approach would be to adhere to the practice of initiating culture based guidance for antibiotics and to restrict unnecessary empirical antimicrobial therapy.
American Psychological Association (APA)
Sharma, Bhawna& Sreenivasan, Priya& Biswal, Manisha& Mahajan, Varun& Suri, Vikas& Sehgal, Inderpaul Singh…[et al.]. 2021. Bacterial coinfections and secondary infections in COVID-19 patients from a tertiary care hospital of northern India : Time to adhere to culture-based practices. Qatar Medical Journal،Vol. 2021, no. 3.
https://search.emarefa.net/detail/BIM-1431727
Modern Language Association (MLA)
Sharma, Bhawna…[et al.]. Bacterial coinfections and secondary infections in COVID-19 patients from a tertiary care hospital of northern India : Time to adhere to culture-based practices. Qatar Medical Journal No. 3 (2021).
https://search.emarefa.net/detail/BIM-1431727
American Medical Association (AMA)
Sharma, Bhawna& Sreenivasan, Priya& Biswal, Manisha& Mahajan, Varun& Suri, Vikas& Sehgal, Inderpaul Singh…[et al.]. Bacterial coinfections and secondary infections in COVID-19 patients from a tertiary care hospital of northern India : Time to adhere to culture-based practices. Qatar Medical Journal. 2021. Vol. 2021, no. 3.
https://search.emarefa.net/detail/BIM-1431727
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-10
Record ID
BIM-1431727