Association of angiotensin-converting enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in polycystic ovarian syndrome : a case-control study
Joint Authors
Sultan, Sikandar
Nazir, Kiran
Lone, Nasira Munawar
Sadique, Shumaila
Eupash, Aminah Zia
Riyad, Siba
Source
Saudi Journal of Biological Sciences
Issue
Vol. 28, Issue 6 (30 Jun. 2021), pp.3483-3489, 7 p.
Publisher
Publication Date
2021-06-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Abstract EN
Polymorphism in the angiotensin-converting enzyme gene (ACE) is responsible for elevated ACE concentrations in plasma.
high ACE levels induce insulin resistance and hyperandrogenism, which are the main attributes of polycystic ovary syndrome (PCOS).
therefore, it was hypothesized that I/D polymorphism plays a role in the pathogenesis of PCOS.
objective : a case-control study was designed to investigate the association of I/D polymorphism of the ACE gene with PCOS in Pakistani women of reproductive age.
methods : ACE I/D polymorphism was assessed in 252 women of age group 16–40 years.
for genotypic analysis, PCR amplification of genomic DNA was carried out.
Statistical analysis was performed to interpret the results using SPSS software.
results : our study showed that PCOS women were more likely to have a high body mass index and waist circumferences.
Most PCOS patients had menstrual irregularities 99.3%, hirsutism 75.2% and cysts in ovaries 66.6%, along with other hyperandrogenic conditions (P-value = 0.001).
the genotypic and allelic frequencies were significantly different between patients and controls.
There was a significant association of three genotypes with the ratio of LH: FSH among PCOS patients (P = 0.05).
anthropometric characters, comorbidities, clinical symptoms, and PCOS conditions showed no statistical significance with ACE polymorphism.
conclusions : ACE I/D polymorphism was not found associated with clinical conditions of PCOS in women of reproductive age.
However, it was associated with atypical steroidogenesis.
So, it indicates that ACE I/D polymorphism aggravates the pathogenesis of PCOS.
American Psychological Association (APA)
Nazir, Kiran& Lone, Nasira Munawar& Sadique, Shumaila& Sultan, Sikandar& Eupash, Aminah Zia& Riyad, Siba. 2021. Association of angiotensin-converting enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in polycystic ovarian syndrome : a case-control study. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3483-3489.
https://search.emarefa.net/detail/BIM-1432633
Modern Language Association (MLA)
Nazir, Kiran…[et al.]. Association of angiotensin-converting enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in polycystic ovarian syndrome : a case-control study. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3483-3489.
https://search.emarefa.net/detail/BIM-1432633
American Medical Association (AMA)
Nazir, Kiran& Lone, Nasira Munawar& Sadique, Shumaila& Sultan, Sikandar& Eupash, Aminah Zia& Riyad, Siba. Association of angiotensin-converting enzyme gene polymorphism in Pakistani women with the atypical steroidogenesis in polycystic ovarian syndrome : a case-control study. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3483-3489.
https://search.emarefa.net/detail/BIM-1432633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 3488-3489
Record ID
BIM-1432633