Central venous line bloodstream infections during hematopoietic stem cell transplantation for primary immunodeficiency disorders

Abstract EN

Background : a central venous line (CVL) is a large-pore intravascular catheter placed into a large vein and dedicated for infusion, withdrawal of blood, and administration of chemotherapy, as in hematopoietic stem cell transplantation (HSCT) patients.

one of the serious complications of CVL is central-line–associated bloodstream infection (CLABSI).

we described CLABSI incidence in primary immunodeficiency disorder (PID) patients who underwent HSCT at queen Rania children’s hospital in a retrospective analysis.

methods : a retrospective analysis of 58 PID patients who were admitted for HSCT from 2014 through 2019 at the bone marrow transplant unit (BMT); positive CLABSI isolates were analysed.

results :out of 58 total patients who underwent HSCT for PID over the study period, 28 (48.3%) were positive for CLABSI.

among those CLABSI-positive patients, 52 CLABSI episodes were isolated over the study period, which were categorized into gram-positive bacteria in 28 episodes (58%), gram-negative bacteria in 19 (36.5%) episodes, and fungi in five (9.5%) episodes.

the most frequently isolated pathogens were staphylococcus epidermises, klebsiella spp., methicillin-resistant staphylococcus aureus (MRSA), and enterococci spp., in 17%, 11.5%, 7.7, and 7.7%, respectively.

conclusions : primary immunodeficiency disorder (PID) patients who underwent HSCT had a different order of CLABSI causative pathogens from what had been reported in paediatric oncological disease and HSCT patients.