دراسة العوامل الإنذارية في الساركوما العظمية عند الأطفال في مشفى الأطفال الجامعي بدمشق
Other Title(s)
A study of prognostic factors of pediatric osteosarcoma in children's university hospital in Damascus
Joint Authors
Source
Issue
Vol. 37, Issue 4 (31 Dec. 2021), pp.91-109, 19 p.
Publisher
Publication Date
2021-12-31
Country of Publication
Syria
No. of Pages
19
Main Subjects
Abstract EN
Background& Aim: Outcomes in pediatric osteosarcoma have dramatically improved over the past few decades, with overall survival rates of 70% and 30% for patients with localized and metastatic disease, respectively.
We aimed to review outcome and prognostic factors that influence overall survival (OS) in osteosarcoma patients at Children’s' University Hospital in Damascus.
Material And Methods: We retrospectively reviewed clinical characteristics and outcomes of 28 patients treated between 2005 and 2015 at a single institution in Syria.
All patients received a uniform chemotherapy regimen consisting of ifosphamide, etoposide, Cisplatin and doxorubicin depending on their tumor stage.
Results: After a follow-up of 60 months, patients with osteosarcoma had 5- year overall and event-free survival rates of approximately 57.1 % and 46.4%, respectively.
The most common primary site was the long bones around the knee (n = 25; 89.2%).9 patient had metastatic disease at diagnosis (8 patients had metastatic disease to lungs, and 1 had metastatic disease to the bones).
In our analysis, adverse prognostic factors were metastases at diagnosis, elevated concentrations of ALP and relapsed disease.
Conclusion: Metastatic disease at diagnosis, elevated concentrations of ALP and relapse have been established as the most powerful prognostic parameters in our analysis.
American Psychological Association (APA)
الخميس، رامي وعثمان حمدان. 2021. دراسة العوامل الإنذارية في الساركوما العظمية عند الأطفال في مشفى الأطفال الجامعي بدمشق. مجلة جامعة دمشق للعلوم الطبية،مج. 37، ع. 4، ص ص. 91-109.
https://search.emarefa.net/detail/BIM-1435920
Modern Language Association (MLA)
الخميس، رامي وعثمان حمدان. دراسة العوامل الإنذارية في الساركوما العظمية عند الأطفال في مشفى الأطفال الجامعي بدمشق. مجلة جامعة دمشق للعلوم الطبية مج. 37، ع. 4 (2021)، ص ص. 91-109.
https://search.emarefa.net/detail/BIM-1435920
American Medical Association (AMA)
الخميس، رامي وعثمان حمدان. دراسة العوامل الإنذارية في الساركوما العظمية عند الأطفال في مشفى الأطفال الجامعي بدمشق. مجلة جامعة دمشق للعلوم الطبية. 2021. مج. 37، ع. 4، ص ص. 91-109.
https://search.emarefa.net/detail/BIM-1435920
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 109
Record ID
BIM-1435920