Fibrinolytic effect of incubating human blood clots in cinnamon cassia using dose dependent : in vitro assays

Abstract EN

Introduction: Herbal medicine is the use of medicinal plants for prevention and treatment of diseases; it has less side effects and they have great effectiveness.

This is an experimental comparative study was conducted in Port-Sudan city.

Aim: this study to determine fibrinolytic activity of Cinnamon Cassia aqueous extract at different concentrations in vitro.

Method: Standardized human whole blood clots were incubated at different concentrations of Cinnamon Cassia (0.

5, 2, 4, 8, and 16).% The D-dimer (DD) levels and WB clot weight were measured for each concentration after 3 hours of incubation using I chroma II analyzer and sensitive balance.

The data was analyzed by SPSS software using one way ANOVA analysis.

Results: The Overall, mean DD (ng/ml) levels were significantly different across samples incubated with Cinnamon Cassia aqueous extract at different concentrations , and the mean pre and post incubation WB clot weights (grams) were significantly decreased.

Conclusion: This study concluded that Cinnamon Cassia aqueous extract possesses fibrinolytic activity following in vitro incubation of WB clot at different concentrations.

Therefore, further investigations for Cinnamon Cassia aqueous extract as a potential alternative fibrinolytict agent is needed.