Effects of Pistacia lentiscus and coriander triphala on adult gastroesophageal reflux disease : a randomized double-blinded clinical trial
Joint Authors
Khodaie, Laleh
Sepehri, Bita
Sadeghi, Fariba
Fazljou, Sayyid Muhammad Bagher
Monirifar, Hassan
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 6 (30 Jun. 2020), pp.1-11, 11 p.
Publisher
Publication Date
2020-06-30
Country of Publication
United Arab Emirates
No. of Pages
11
Main Subjects
Abstract EN
Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation.
Conven- tional treatment is done by proton pump inhibitors.
In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders.
Objectives: This study aimed to assess the effects of Pistacia lentiscus (mastic) and Coriander Triphala on reflux symptoms compared to omeprazole in a double-blinded randomized clinical trial.
Methods: In a double-blinded, multicenter, randomized clinical trial, we assessed the effects of Pistacia lentiscus L., Coriander Triphala, and omeprazole on the symptoms of GERD in Tabriz, Iran, in 2018 - 2019.
Thus, 105 patients with GERD symptoms were assigned randomly to three groups as group A (Pistacia lentiscus L., 1000 mg/TDS), group B (Coriander Triphala, 1000 mg/TDS), and group C (omeprazole, 20 mg/day plus five placebo capsules per day).
The assessments were done at the beginning and the end of the study using FSSG, VAS, RS, and GERD-HRQL questionnaires.
Results: In the beginning, no significant differences were observed between the groups in the background characteristics.
There was no statistically significant difference between Pistacialentiscus, Coriander Triphala, and omeprazole in the improvement of FSSG, VAS, GERD-HRQL, and reflux scores.
In all groups, the FFSG, VAS, reflux, and GERD-HRQL scores significantly decreased and improved after four weeks of intervention compared to the respective baselines.
The FSSG score improvements after four weeks of intervention were 73.68%, 83.33%, and 68.62%, in groups A, B, and C, respectively.
The VAS score improvements were 66.66%, 75.00%, and 62.50% in groups A, B, and C, respectively.
Improvements in GERD-HRQL were 90.00%, 91.28%, and 82.00%, in groups A, B, and C, respectively.
Reflux improvements were 66.66%, 80.00%, and 66.66% in groups A, B, and C, respectively.
Conclusions: The results showed that Pistacia lentiscus and Coriander Triphala are as effective as omeprazole in the treatment of GERD.
American Psychological Association (APA)
Sadeghi, Fariba& Fazljou, Sayyid Muhammad Bagher& Sepehri, Bita& Khodaie, Laleh& Monirifar, Hassan. 2020. Effects of Pistacia lentiscus and coriander triphala on adult gastroesophageal reflux disease : a randomized double-blinded clinical trial. Iranian Red Crescent Medical Journal،Vol. 22, no. 6, pp.1-11.
https://search.emarefa.net/detail/BIM-1437552
Modern Language Association (MLA)
Sadeghi, Fariba…[et al.]. Effects of Pistacia lentiscus and coriander triphala on adult gastroesophageal reflux disease : a randomized double-blinded clinical trial. Iranian Red Crescent Medical Journal Vol. 22, no. 6 (Jun. 2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1437552
American Medical Association (AMA)
Sadeghi, Fariba& Fazljou, Sayyid Muhammad Bagher& Sepehri, Bita& Khodaie, Laleh& Monirifar, Hassan. Effects of Pistacia lentiscus and coriander triphala on adult gastroesophageal reflux disease : a randomized double-blinded clinical trial. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 6, pp.1-11.
https://search.emarefa.net/detail/BIM-1437552
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-11
Record ID
BIM-1437552