Serum bone minerals in patients of sickle cell anemia

Abstract EN

Introduction single nucleotide substitution A by T AT 17TH nucleotide of the 6th amino-acid Glutamic acid by valine in beta subunit of Hb (HbA) results in formation of sickle hemoglobin (HbS), Sickle bone syndrome is a public health problem to sicklers (disturbed serum bone minerals and bone density sickle cell crisis pain ).

Because of genetic prevalence of sickle anaemia gene in Southern Sudan, sickle cell anaemia is a serious health issue and common cause of paediatrics admission at hospitals and the significance of measuring serum calcium, phosphorous and magnesium clarify the necessity to conduct this study.Which aimed to evaluate Ca, P and Mg Sudanese sicklers and correlate them to bone density and sickle cell crisis pain.

Methods: A descriptive Case control study conducted in Southern Darfur Nyala-city involving Sudanese sicklers 50 and age matched control group 50,Hb electrophoresis records and clinical data for patients with sickle disease (known cases of SCD) serum Ca, P and Mg and Albumin were estimated using fully automated chemistry analyzer ( Mindray BS-200) Results: The results show normal magnesium levels with significant difference between serum magnesium levels among patients (2.43 (0.37),mg/dl) and controls (1.99 (0.47)mg/dl) p value 0.00, the mean serum calcium levels was significantly lower in the sickle cell disease group (8.4 (0.9 mg/dl)) compared to controls (9.4 (0.6) mg/dl) p value 0.00 .

While the mean serum inorganic phosphorous was significantly higher in SCD group (6.6 (1.8) mg/dl) compared to control group (3.9 (0.82) mg/dl).

Conclusion: Normomagnesimia hyperphosphatemia and hypocalcaemia are observed in SCD compared to controls.