Serum bone minerals in patients of sickle cell anemia
Joint Authors
Abd Rabbih, Abd al-Karim A.
Ibrahim, Salah al-Din Abbas
Source
Sudan Medical Laboratory Journal
Issue
Vol. 9, Issue 1 (31 Dec. 2021), pp.8-14, 7 p.
Publisher
Omdurman Islamic University Faculty of Medical Laboratory
Publication Date
2021-12-31
Country of Publication
Sudan
No. of Pages
7
Main Subjects
Abstract EN
Introduction single nucleotide substitution A by T AT 17TH nucleotide of the 6th amino-acid Glutamic acid by valine in beta subunit of Hb (HbA) results in formation of sickle hemoglobin (HbS), Sickle bone syndrome is a public health problem to sicklers (disturbed serum bone minerals and bone density sickle cell crisis pain ).
Because of genetic prevalence of sickle anaemia gene in Southern Sudan, sickle cell anaemia is a serious health issue and common cause of paediatrics admission at hospitals and the significance of measuring serum calcium, phosphorous and magnesium clarify the necessity to conduct this study.Which aimed to evaluate Ca, P and Mg Sudanese sicklers and correlate them to bone density and sickle cell crisis pain.
Methods: A descriptive Case control study conducted in Southern Darfur Nyala-city involving Sudanese sicklers 50 and age matched control group 50,Hb electrophoresis records and clinical data for patients with sickle disease (known cases of SCD) serum Ca, P and Mg and Albumin were estimated using fully automated chemistry analyzer ( Mindray BS-200) Results: The results show normal magnesium levels with significant difference between serum magnesium levels among patients (2.43 (0.37),mg/dl) and controls (1.99 (0.47)mg/dl) p value 0.00, the mean serum calcium levels was significantly lower in the sickle cell disease group (8.4 (0.9 mg/dl)) compared to controls (9.4 (0.6) mg/dl) p value 0.00 .
While the mean serum inorganic phosphorous was significantly higher in SCD group (6.6 (1.8) mg/dl) compared to control group (3.9 (0.82) mg/dl).
Conclusion: Normomagnesimia hyperphosphatemia and hypocalcaemia are observed in SCD compared to controls.
American Psychological Association (APA)
Ibrahim, Salah al-Din Abbas& Abd Rabbih, Abd al-Karim A.. 2021. Serum bone minerals in patients of sickle cell anemia. Sudan Medical Laboratory Journal،Vol. 9, no. 1, pp.8-14.
https://search.emarefa.net/detail/BIM-1437733
Modern Language Association (MLA)
Ibrahim, Salah al-Din Abbas& Abd Rabbih, Abd al-Karim A.. Serum bone minerals in patients of sickle cell anemia. Sudan Medical Laboratory Journal Vol. 9, no. 1 (2021), pp.8-14.
https://search.emarefa.net/detail/BIM-1437733
American Medical Association (AMA)
Ibrahim, Salah al-Din Abbas& Abd Rabbih, Abd al-Karim A.. Serum bone minerals in patients of sickle cell anemia. Sudan Medical Laboratory Journal. 2021. Vol. 9, no. 1, pp.8-14.
https://search.emarefa.net/detail/BIM-1437733
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-14
Record ID
BIM-1437733