Evaluation of serum uric acid levels among hypertensive pregnant women in Khartoum state

Abstract EN

Background: Hypertensive disorders complicate 5–10% of all pregnancies and contribute greatly to maternal morbidity and mortality.

Hyperuricemia has played a significant role in the pathogenesis of the disease and often precedes clinical manifestations.

Objective: in this study, we aimed to evaluate the serum uric acid levels in hypertensive pregnant women compared to normotensive pregnant women with different trimesters.

Materials and Methods: An analytical comparative hospital based study, the study conducted in Khartoum state, during the period from April to October 2019.

A total of 210 pregnant women were enrolled, 90 normotensive pregnant women with different trimesters, 90 preeclampsia women and 30 pregnant women with eclampsia.

All Serum uric acid concentrations were estimated by enzymatic method in fully Automated Biochemistry Analyzer (Mindary, china).

Results: Among the normotensive pregnant women, the percentage of primigravidae was 36(40%) and the multigravidae was 54 (60%), and in the group of pregnant women with preeclampsia, the primigravidae was 41(34%) and the multigravidae 49 (66%), while it was 9(30%) and 21 (70%) respectively In the group of pregnant women with eclampsia, the primary gravida 9(30%) and the multigravida 21 (70%).

Serum uric acid level was significantly increased in pregnant women with preeclampsia and eclampsia compared with normotensive pregnant women (p = 0.000).

Also the serum uric acid was significantly increased in pregnant women in the third trimester compared to first and second trimester normal pregnant women (p= 0.000).

Conclusion: Serum uric acid had a highly significant increase in hypertensive pregnant women compared with normotensive pregnant women.

The study observed that the serum uric acid may have a predictive marker role of hypertensive pregnant women.