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Intracellular fibronectin expression in invasive breast carcinoma : is it related to significant clinicopathological prognostic factors ?
Joint Authors
Zadah, Fereshteh Muhammadi
al-Haydari, Sumayyah
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 4 (30 Apr. 2020), pp.1-8, 8 p.
Publisher
Publication Date
2020-04-30
Country of Publication
United Arab Emirates
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Fibronectin plays a key role in the extracellular matrix.
The expression of fibronectin and its impact on tumor behav- ior have been studied in several tumors such as breast carcinoma.
Objectives: We aimed at investigating the immunohistochemical expression of intracellular fibronectin in breast carcinoma and its relationship with significant clinicopathological factors.
Methods: This case-control study was conducted on 125 formalin-fixed and paraffin-embedded tissue blocks, including 50 invasive breast carcinomas (tumor group) and their adjacent normal tissue (tumor control group), and 25 normal control samples from mammoplasty (normal control group).
The samples were obtained from the pathology archive of Alzahra Hospital, Isfahan, Iran, from 2016 to 2018.
All the 125 samples were stained immunohistochemically by the fibronectin antibody.
Intracellular fibronectin expression was then compared between the three groups.
Moreover, the relationship between fibronectin expression and some clinicopathological factors was evaluated in the tumor group.
Results: Fibronectin staining intensity and extent showed no significant difference between the normal control and tumor control groups (P-Value = 0.65 and 0.065, respectively), while the tumor group showed a significant difference from both normal control and tumor control groups in fibronectin staining intensity (P-Value = 0.002 and < 0.001, respectively) and fibronectin staining extent (P-Value < 0.001).
In addition, a significant relationship between fibronectin expression in tumor samples and fibronectin staining intensity and tumor grade was observed (P-Value = 0.01).
However, fibronectin expression did not show any significant relationship with age, tumor size, tumor subtype, and lymph node status.
Conclusions: Intracellular fibronectin expression seems to be a tendency observed in some breast carcinomas.
Normal breast tis- sue, whether adjacent to carcinoma or normal control, does not show such a tendency.
Despite the significant relationship between fibronectin expression and carcinoma grade, fibronectin expression did not show any significant relationship with tumor size and lymph node status.
American Psychological Association (APA)
Zadah, Fereshteh Muhammadi& al-Haydari, Sumayyah. 2020. Intracellular fibronectin expression in invasive breast carcinoma : is it related to significant clinicopathological prognostic factors ?. Iranian Red Crescent Medical Journal،Vol. 22, no. 4, pp.1-8.
https://search.emarefa.net/detail/BIM-1439420
Modern Language Association (MLA)
Zadah, Fereshteh Muhammadi& al-Haydari, Sumayyah. Intracellular fibronectin expression in invasive breast carcinoma : is it related to significant clinicopathological prognostic factors ?. Iranian Red Crescent Medical Journal Vol. 22, no. 4 (Apr. 2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1439420
American Medical Association (AMA)
Zadah, Fereshteh Muhammadi& al-Haydari, Sumayyah. Intracellular fibronectin expression in invasive breast carcinoma : is it related to significant clinicopathological prognostic factors ?. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 4, pp.1-8.
https://search.emarefa.net/detail/BIM-1439420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 7-8
Record ID
BIM-1439420