Combined therapy following spinal cord injury : synergistic neuroprotective effects of ceftriaxone and n-acetylcysteine
Joint Authors
Salimi, Omid
Vand, Ali Asghar Muhammad
Charkhpour, Muhammad
Mahmudi, Jawad
Asl, Buhlul Habibi
Kalan, Abbas Ibrahimi
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 22, Issue 4 (30 Apr. 2020), pp.1-6, 6 p.
Publisher
Publication Date
2020-04-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Spinal Cord Injury (SCI) is one of the leading causes of severe neurological deficits worldwide.
The pathophysiology of SCI includes a primary injury followed by a cascade of secondary biochemical and cellular changes.
Current pharmacological op- tions are limited for significant recovery from SCI.
The β-lactam antibiotic ceftriaxone (CEF) and N-acetylcysteine (NAC) have shown to induce neuroprotection in animal models of neurodegenerative disorders.
Objectives: This study aimed to evaluate the effects of CEF, NAC, and their combination on the functional recovery and histological damage in experimental SCI.
Methods: Rats were randomly divided into four groups (n = 7): Saline, CEF, NAC, and CEF + NAC.
Then, SCI was performed on rats under general anesthesia using the Neurosciences Research Center (NSRC) impactor.
Locomotor recovery following SCI was mon- itored using the locomotor rating scale of Basso, Beattie, and Bresnahan (BBB).
At the end of the study, all rats were sacrificed, and spinal cord cross-sections were stained with hematoxylin and eosin for histopathological evaluation.
Results: The CEF and NAC administration, either alone or in combination (CEF + NAC), significantly improved locomotor recovery following SCI in rats when compared to the saline group.
The histological analysis showed that the severity of histopathological lesion in the spinal cord of rats was significantly lower in the CEF, NAC, and CEF + NAC groups than in the saline group.
Conclusions: Treatment with CEF and NAC, either separately or in combination, promotes locomotor recovery following SCI, which is associated with the effective reduction of the histopathological lesion.
American Psychological Association (APA)
Salimi, Omid& Vand, Ali Asghar Muhammad& Kalan, Abbas Ibrahimi& Charkhpour, Muhammad& Mahmudi, Jawad& Asl, Buhlul Habibi. 2020. Combined therapy following spinal cord injury : synergistic neuroprotective effects of ceftriaxone and n-acetylcysteine. Iranian Red Crescent Medical Journal،Vol. 22, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-1439424
Modern Language Association (MLA)
Salimi, Omid…[et al.]. Combined therapy following spinal cord injury : synergistic neuroprotective effects of ceftriaxone and n-acetylcysteine. Iranian Red Crescent Medical Journal Vol. 22, no. 4 (Apr. 2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1439424
American Medical Association (AMA)
Salimi, Omid& Vand, Ali Asghar Muhammad& Kalan, Abbas Ibrahimi& Charkhpour, Muhammad& Mahmudi, Jawad& Asl, Buhlul Habibi. Combined therapy following spinal cord injury : synergistic neuroprotective effects of ceftriaxone and n-acetylcysteine. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-1439424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-1439424