Frequency of insulin resistance in people with thyroid dysfunction
Joint Authors
al-Wali, Shadha Abd Allah
Abd al-Aziz, Sulaf I.
Source
Sudan Journal of Medical Sciences
Issue
Vol. 16, Issue 4 (31 Dec. 2021), pp.531-539, 9 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2021-12-31
Country of Publication
Sudan
No. of Pages
9
Main Subjects
Abstract EN
Background: Thyroid dysfunction is an endocrine disorder with a recognized association with type 2 diabetes mellitus.
Thyroid hormones have a remarkable effect on glucose metabolism and can cause insulin resistance (IR).
This study was aimed at assessing the relationship between IR and thyroid dysfunction.
Methods: This case–control study was conducted at the endocrinology outpatient clinics of Ibrahim Malik Hospital and Omdurman Military Hospital in Khartoum State, Sudan between May 2018 and January 2019.
Fasting blood glucose (FBG), fasting insulin level, and thyroid function test (TFT) were measured for each candidate and IR was estimated using the HOMA-IR equation.
Results: Thirty-one patients with thyroid dysfunction and fifty-seven control participants were enrolled.
The highest mean FBG was found among cases (105.3 ± 15.7 mg/dl) compared to the controls (97 ± 12.1 mg/dl), but the difference was not statistically significant (P-value = 0.598).
The mean fasting insulin level was 9.22 ± 4 IU/ml in the cases and 9.4 ± 4.2 IU/ml in controls, without a significant difference (P-value = 0.681).
The highest HOMA-IR score was found among cases (2.4 ± 1.2).
It was 2.4 ± 1.3 in hyperthyroidism, 2.3 ± 1.1 in hypothyroidism, and 2.4 ± 1.2 in controls, and the difference was insignificant (P-value = 0.859).
IR was higher in the cases (58.1%) compared to the controls (52.6%) but again not statistically significant (P-value = 0.396).
Among cases, IR was encountered in 61.9% and 50% of hyperthyroid and hypothyroid patients, respectively.
Conclusion: Patients with thyroid dysfunction have some level of IR that was not statistically significant when compared with controls.
American Psychological Association (APA)
al-Wali, Shadha Abd Allah& Abd al-Aziz, Sulaf I.. 2021. Frequency of insulin resistance in people with thyroid dysfunction. Sudan Journal of Medical Sciences،Vol. 16, no. 4, pp.531-539.
https://search.emarefa.net/detail/BIM-1439657
Modern Language Association (MLA)
al-Wali, Shadha Abd Allah& Abd al-Aziz, Sulaf I.. Frequency of insulin resistance in people with thyroid dysfunction. Sudan Journal of Medical Sciences Vol. 16, no. 4 (2021), pp.531-539.
https://search.emarefa.net/detail/BIM-1439657
American Medical Association (AMA)
al-Wali, Shadha Abd Allah& Abd al-Aziz, Sulaf I.. Frequency of insulin resistance in people with thyroid dysfunction. Sudan Journal of Medical Sciences. 2021. Vol. 16, no. 4, pp.531-539.
https://search.emarefa.net/detail/BIM-1439657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 538-539
Record ID
BIM-1439657