Datura Stramonium leaf extract toxic effects on testis in swiss albino mice Mus musculus

Joint Authors

al-Wirfli, Suad Muhammad
Muhammad, Abd Allah I.
al-Zawawi, Atiqah Ghayth
Muhammad, Raja Abd Allah

Source

Scientific Journal for the Faculty of Science-Sirte University

Issue

Vol. 1, Issue 1 (31 Oct. 2021), pp.47-52, 6 p.

Publisher

Sirte University Faculty of Science

Publication Date

2021-10-31

Country of Publication

Libya

No. of Pages

6

Main Subjects

Zoology

Abstract EN

The notorious weed, jimson weed (Datura stramonium L.) is a hallucinogenic plant that is both toxic and medicinal.

The presence of tropane alkaloids, which contain a methylation nitrogen atom (N-CH3) and inhibit neurotransmitters in the brain, is thought to be responsible for the plant's neurotoxicity.

Toxic symptoms have been linked to the recreational use of D.

stramonium, according to ethnomedicine.

This investigation has been designed to examine the toxicity and describe the possible changes in the structural function of vital organs, following the orally intubation of non-lethal doses of D.

stramonium leaves crude aqueous extract.

Through preliminary trials, crude aqueous extract.

Of 200 mg leaves per kilogram body weight was established as a tolerable non-lethal dose.

Three doses 0.36, 0.7, and 4 mg/kg were orally weekly, administered to the male mice in a 0.1 ml volume.

Acute toxicity studies were accomplished through oral intubation of three dosages in each case.

Observation and mortality were reported for 24 .48, 72 hours.

Prolonged toxicity was performed through the administration of weekly, single doses oral for 40 days.

The observation was made on the mice's testis weight and histological abnormality of a testis organ.

American Psychological Association (APA)

al-Wirfli, Suad Muhammad& Muhammad, Abd Allah I.& al-Zawawi, Atiqah Ghayth& Muhammad, Raja Abd Allah. 2021. Datura Stramonium leaf extract toxic effects on testis in swiss albino mice Mus musculus. Scientific Journal for the Faculty of Science-Sirte University،Vol. 1, no. 1, pp.47-52.
https://search.emarefa.net/detail/BIM-1440096

Modern Language Association (MLA)

al-Wirfli, Suad Muhammad…[et al.]. Datura Stramonium leaf extract toxic effects on testis in swiss albino mice Mus musculus. Scientific Journal for the Faculty of Science-Sirte University Vol. 1, no. 1 (Oct. 2021), pp.47-52.
https://search.emarefa.net/detail/BIM-1440096

American Medical Association (AMA)

al-Wirfli, Suad Muhammad& Muhammad, Abd Allah I.& al-Zawawi, Atiqah Ghayth& Muhammad, Raja Abd Allah. Datura Stramonium leaf extract toxic effects on testis in swiss albino mice Mus musculus. Scientific Journal for the Faculty of Science-Sirte University. 2021. Vol. 1, no. 1, pp.47-52.
https://search.emarefa.net/detail/BIM-1440096

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 52-53

Record ID

BIM-1440096