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Antidiabetic activity of origanum majorana l in glucose fed normal rats and alloxan-induced diabetic rats
Joint Authors
Mahmud, Iman A. A.
Idris F. O.
Adam, Shama I. Y.
Source
Sudan Journal of Science and Technology
Issue
Vol. 21, Issue 2 (31 Dec. 2020), pp.151-162, 12 p.
Publisher
Sudan University of Science and Technology Deanship of Scientific Research
Publication Date
2020-12-31
Country of Publication
Sudan
No. of Pages
12
Main Subjects
Engineering & Technology Sciences (Multidisciplinary)
Abstract EN
Glycemic management medications have become increasingly complex and controversial.
Plant-based traditional medicine has been proven worldwide as alternative treatment for diabetes.To evaluate the antidiabetic efficiency of Origanum majorana L extracts in normal and diabetic rats.Diabetes (Type 1 and type 2) were induced by administration of single intraperitoneal dose of 150 mg/kg of alloxan and ingestion of 20 mg/km of 50% w/v glucose once a day for 30 days respectively.
The aqueous and methanolic extracts of O.
majorana L was prepared and given to diabetic and hyperglycemic rats at 250 and 500 mg/kg/day orally for 30 days.
Oral glucose tolerance test (GTT) was conducted in normal healthy rats using single dose of 350 mg/kg of each extract.
At 30-day blood samples were collected for biochemical analysis.
The result shows that alloxan induced diabetic groups treated with plant extracts had significantly lower fasting glucose level and glycosylated haemoglobin and improved lipid profile, insulin concentration was insignificantly changed.
Blood glucose and cholesterol values were significantly decreased in glucose loaded rats treated with water extract at low dose.
This study suggests that aqueous and methanolic extracts of O.
majorana possess a potential antidiabetic activity for both type1 and type2 diabetes.
American Psychological Association (APA)
Mahmud, Iman A. A.& Idris F. O.& Adam, Shama I. Y.. 2020. Antidiabetic activity of origanum majorana l in glucose fed normal rats and alloxan-induced diabetic rats. Sudan Journal of Science and Technology،Vol. 21, no. 2, pp.151-162.
https://search.emarefa.net/detail/BIM-1440579
Modern Language Association (MLA)
Idris F. O.…[et al.]. Antidiabetic activity of origanum majorana l in glucose fed normal rats and alloxan-induced diabetic rats. Sudan Journal of Science and Technology Vol. 21, no. 2 (Dec. 2020), pp.151-162.
https://search.emarefa.net/detail/BIM-1440579
American Medical Association (AMA)
Mahmud, Iman A. A.& Idris F. O.& Adam, Shama I. Y.. Antidiabetic activity of origanum majorana l in glucose fed normal rats and alloxan-induced diabetic rats. Sudan Journal of Science and Technology. 2020. Vol. 21, no. 2, pp.151-162.
https://search.emarefa.net/detail/BIM-1440579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 160-162
Record ID
BIM-1440579