Clinical staging and flowcytometric cd38 and zap-70 prognostic indicators in Sudanese patients with chronic lymphocytic leukemia
Joint Authors
Abd al-Qadir, Inam Abd al-Rahman
al-Tayyib, Nada Hasan
al-Tayyib, Usamah Ali
Fadl, Iman Abbas
Ali, Suad Fadl Allah
Abd al-Rahman, Eldirdiri M.
Source
Sudan Journal of Medical Sciences
Issue
Vol. 15, Issue 1 (31 Mar. 2020), pp.43-55, 13 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2020-03-31
Country of Publication
Sudan
No. of Pages
13
Main Subjects
Abstract EN
Background: The clinical course of chronic lymphocytic leukemia is highly variable.
The determination of ZAP70 and CD38 is increasingly utilized as prognostic factor for chronic lymphocytic leukemia.
The aim of conducting this study was to investigate the frequency of CD38 and ZAP70 expression among Sudanese Chronic lymphocytic leukemia (CLL) patients and to relate them to the Binet and Rai clinical staging systems.
Method: A total of 93 patients (mean age; 62.29 ± 11.68, sd) were enrolled in this cross sectional study.
CD38 and ZAP70 expression levels were measured with four color flowcytometry using the cut-off values of 20% for ZAP70 and 30% for CD38 expression.
Staging was assessed by using clinical examination and CBC for all patients.
Data were analyzed using the Statistical Package for Social science for Windows (SPSS), version 22.
Results: There were 93 CLL patients and the median age of the group was 63 years (36–95 years).
About 71% of the patients presented with lymphadenopathy, 53.8% with splenomegaly, 73.1% with anemia, and 45.2% with thrombocytopenia.
There was higher frequency of Binet stage C and Rai stage IV (62 [66.6%] patients and 34 [36.5%] patients, respectively).
In addition, CD38 and ZAP70 showed higher frequency among Binet and Rai advance stages.
ZAP70 and CD38 positivity were detected in 21 patients (22.6%) and 31 patients (33.3%), respectively.
There was no statistically significant association between ZAP70 and CD38 and clinical staging systems (p > 0.05).
Conclusion: No significant association was observed between Flowcytometric (CD38 and Zap70) Prognostic Indicators and clinical staging systems.
American Psychological Association (APA)
Abd al-Qadir, Inam Abd al-Rahman& al-Tayyib, Nada Hasan& al-Tayyib, Usamah Ali& Fadl, Iman Abbas& Ali, Suad Fadl Allah& Abd al-Rahman, Eldirdiri M.. 2020. Clinical staging and flowcytometric cd38 and zap-70 prognostic indicators in Sudanese patients with chronic lymphocytic leukemia. Sudan Journal of Medical Sciences،Vol. 15, no. 1, pp.43-55.
https://search.emarefa.net/detail/BIM-1440618
Modern Language Association (MLA)
Abd al-Qadir, Inam Abd al-Rahman…[et al.]. Clinical staging and flowcytometric cd38 and zap-70 prognostic indicators in Sudanese patients with chronic lymphocytic leukemia. Sudan Journal of Medical Sciences Vol. 15, no. 1 (2020), pp.43-55.
https://search.emarefa.net/detail/BIM-1440618
American Medical Association (AMA)
Abd al-Qadir, Inam Abd al-Rahman& al-Tayyib, Nada Hasan& al-Tayyib, Usamah Ali& Fadl, Iman Abbas& Ali, Suad Fadl Allah& Abd al-Rahman, Eldirdiri M.. Clinical staging and flowcytometric cd38 and zap-70 prognostic indicators in Sudanese patients with chronic lymphocytic leukemia. Sudan Journal of Medical Sciences. 2020. Vol. 15, no. 1, pp.43-55.
https://search.emarefa.net/detail/BIM-1440618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 33-55
Record ID
BIM-1440618