Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazon
Joint Authors
Ashraf, Kamran
Sultan, Sadia
al-Hariri, Muhammad Taha
Ramasamy, Kalavathy
Fatmi, M. Qaiser
Shehzad, Adeeb
Rahim, Fazal
Selvaraj, Manikandan
Lim, Siong Meng
Herizal, Muhammad
Halim, Sobia Ahsan
Source
Journal of Saudi Chemical Society
Issue
Vol. 23, Issue 8 (31 Dec. 2019), pp.1168-1179, 12 p.
Publisher
Publication Date
2019-12-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Abstract EN
To find out effective anticancer compounds we synthesized (1–30) derivatives of 4- isopropylbenzoylhydrazone and evaluated for anticancer potential.
The compounds 3, 9, 12, 23, 26 and 28 showed better activities ranging (0.39–1.1 mg/ml) than the standard (1.53 ± 0.01 mg/ ml).
In line with this, compounds 2, 6, 24, 25 and 29 exhibited better activities compared to the second standard (5FU 4.60 ± 0.01 mg/ml).
The best molecular docked complex between the BRCA1 structure and the 1–30 derivatives were analyzed based on the Glide docked score and binding orientation for both the SP and XP mode.
The 2D-QSAR analysis reflected a significant correlation between the experimental and the predicted biological activities.
The above-mentioned compounds were also assessed by various spectroscopic techniques.
American Psychological Association (APA)
al-Hariri, Muhammad Taha& Sultan, Sadia& Herizal, Muhammad& Fatmi, M. Qaiser& Selvaraj, Manikandan& Ramasamy, Kalavathy…[et al.]. 2019. Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazon. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1168-1179.
https://search.emarefa.net/detail/BIM-1443241
Modern Language Association (MLA)
al-Hariri, Muhammad Taha…[et al.]. Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazon. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1168-1179.
https://search.emarefa.net/detail/BIM-1443241
American Medical Association (AMA)
al-Hariri, Muhammad Taha& Sultan, Sadia& Herizal, Muhammad& Fatmi, M. Qaiser& Selvaraj, Manikandan& Ramasamy, Kalavathy…[et al.]. Synthesis, anticancer, molecular docking and QSAR studies of benzoylhydrazon. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1168-1179.
https://search.emarefa.net/detail/BIM-1443241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1178-1179
Record ID
BIM-1443241