Assessment of plasma zonulin and copeptin levels in childhood

Abstract EN

Background : obesity is a critical problem among children and adolescents and we in need to discover novel biomarkers for obesity and its metabolic disorders.

objective : to assess the relation between plasma zonulin and copeptin and their relations with the metabolic disturbances in Egyptian children.

methodology : case-control study conducted in the national research Centre (NRC) ; included 111 children ; 45 males (8.74 ± 1.60 years) and 66 females (8.78 ± 1.73 years).

history taking, clinical examination, blood pressure measurement, body weight, height, bmi and waist circumference parameters lipid profile, zonulin and copeptin levels were measured.

results : zonulin had significant negative correlations (r = 0.346, p = 0.000), copeptin had significant positive correlations with age (r = 0.384, p = 0.000), diastolic blood pressure (r = 0.037, p = 0.011), weight (r = 0.374, p = 0.000), height (p = 0.002, p = 0.000), BMI (r = 0.378, p = 0.000), and WC (r = 0.353, p = 0.000).

insignificant correlations between zonulin and copeptin with lipid profile and significant negative correlation between zonulin and copeptin (r = 0.384, p = 0.0001).

conclusion : significant negative relations between serum zonulin and copeptin, and significant reverse relations with blood pressure and anthropometric measurements.