Effect of standard and low protein diets containing gum Arabic on hyperuricemic rats

Abstract EN

Hyperuricemia is a common disorder that affects patients of all ages and genders.

The most common manifestation of hyperuricemia is gout.

Gum Arabic (GA) is a complex polysaccharide , believed to be an excellent curative for hyperuricemia,The present study is aimed to investigate the effect of diets containing gum arabic on hyperuricemic rats.

A specimen of forty nine albino rats were divided into two main groups.

The first main group (7 rats) fed on basal diet (BD) as control negative group, the second main group (42 rats) treated with 30% fructose in drinking water for 6 weeks to induce hyperuricemia ,and treated with standard diet or low protein diet plus gum arabic in different proportions (5% and 10%).The experiment lasted for 4 weeks.Groups which treated with standard or low protein diet containing 10% Gum arabic recorded the best results as decrement the % of body weight gain and kidney weight / body weight% as compared to the other groups with hyperuricemia.

the best results in decreasing glucose and kidney functions which including serum uric acid, urea nitrogen and creatinine were recorded for the hyperuricemic group fed on a low protein diet containing 10% Gum arabic, followed by the group which suffer from hyperuricemia and treated with a standard diet containing 10% Gum arabic.

Also feeding rats with hyperuricemia on a standard diet or low protein diet containing (5% and 10% Gum arabic) improved the lipid profile and the liver enzymes (AST, ALT and ALP), as compared to the positive control groups.

conculsion low protein diet plus to gum arabic improve both liver and kidney function, specially for rats suffering from hyperuriecemia