The effect of supplementation with quercetin, catechin and rich food of them on immune system in experimental rats

Abstract EN

Aim of the study: to assess the effect of Quercetin (Q), catechin (CT) and rich food of them supplementation on immune system in rats.

Materials and Methods: 36 rats were allocated in 6 groups, first group (6 rats) served as (-ve) negative control group and fed on basal diet, while main (30 rats) drank polluted water with cadmium chloride (CD) 40mg/k.g for 40 days (to induced immunity inhibition) and the second group was set as a positive control group (+ve) that was fed the basic diet only.

Then rats were divided equally to five groups (2, 3, 4, 5, 6) and fed on basal diet only (positive control) or with Q commercial at 45mg swallowed orally, red dried onions as a natural source Q by 12 g, CT commercial at 7.5mg Swallowed orally and green tea (GT) powder as a natural source CT by 5.5 g respectively, treatments were for 21 days as mentioned.

Results: In all treatment groups there were an improvement in IgG, RBC, HGB, HCH and MCHC to approach the negative control level (Healthy group).While increased in the SOD, GPX and CAT compared with the control positive group.

Also decreased in the MCV, urea, u.acid, creatinine, GOT, GPT and T.P compared with the control positive group.

While the better result was in group 4 Q natural as it improvement in Urea, creatinine, GPX, CAT, SOD and IgG compared with all treatment groups.

Conclusion: Consumption Q and CT from natural and commercial sources had important role in Strengthened the immune system, and reduced deleterious effects of CD in rats.