Coronavirus disease 2019 in solid organ transplant recipients in the setting of proactive screening and contact tracing of Qatar
Joint Authors
al-Musallamni, Muna A.
Umrani, Ali S.
al-Attar, Rand A.
al-Shaar, Shahd H.
Abu Jarir, Sulayman H.
Hashim, Samar M.
Iqbal, Fatimah
Rustum, Fatimah
Uthman, Miftah
Source
Issue
Vol. 2021, Issue 2 (31 Aug. 2021), pp.1-11, 11 p.
Publisher
Publication Date
2021-08-31
Country of Publication
Qatar
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Clinical data on Coronavirus Disease 2019 (COVID-19) in solid organ transplant (SOT) recipients are limited.
We herein report the initial clinical experience with COVID-19 in SOT recipients in Qatar.
Methods: All SOT recipients with laboratory-con- firmed COVID-19 up to May 23, 2020 were included.
Demographic and clinical data were extracted retro- spectively from the hospital's electronic health records.
Categorical data are presented as frequency and percentages, while continuous variables are summarized as medians and ranges.
Results: Twenty-four SOT recipients with COVID-19 were identified (kidney 16, liver 6, heart 1, and liver and kidney 1).
Organ transplantation preceded COVID-19 by a median of 60 months (range 1.7– 184).
The median age was 57 years (range 24–72), and 9 (37.5%) transplant recipients were females.
Five (21%) asymptomatic patients were diagnosed through proactive screening.
For the rest, fever (15/19) and cough (13/19) were the most frequent presenting symptoms.
Five (20.8%) patients required invasive mechanical ventilation in the intensive care unit (ICU).
Eleven (46%) patients developed acute kidney injury, including three in association with drug- drug interactions involving investigational COVID-19 therapies.
Maintenance immunosuppressive therapy was modified in 18 (75%) patients, but systemic corticosteroids were not discontinued in any.
After a median follow-up of 226 days (26–272), 20 (83.3%) patients had been discharged home, 2 (8.3%) were still hospitalized, 1 (4.2%) was still in the ICU, and 1 (4.2%) had died.
Conclusions: Our results suggest that asymptomatic COVID-19 is possible in SOT recipients and that overall outcomes are not uniformly worse than those in the general population.
The results require confirmation in large, international cohorts.
American Psychological Association (APA)
al-Attar, Rand A.& al-Shaar, Shahd H.& Uthman, Miftah& Abu Jarir, Sulayman H.& Hashim, Samar M.& Iqbal, Fatimah…[et al.]. 2021. Coronavirus disease 2019 in solid organ transplant recipients in the setting of proactive screening and contact tracing of Qatar. Qatar Medical Journal،Vol. 2021, no. 2, pp.1-11.
https://search.emarefa.net/detail/BIM-1448217
Modern Language Association (MLA)
al-Attar, Rand A.…[et al.]. Coronavirus disease 2019 in solid organ transplant recipients in the setting of proactive screening and contact tracing of Qatar. Qatar Medical Journal No. 2 (2021), pp.1-11.
https://search.emarefa.net/detail/BIM-1448217
American Medical Association (AMA)
al-Attar, Rand A.& al-Shaar, Shahd H.& Uthman, Miftah& Abu Jarir, Sulayman H.& Hashim, Samar M.& Iqbal, Fatimah…[et al.]. Coronavirus disease 2019 in solid organ transplant recipients in the setting of proactive screening and contact tracing of Qatar. Qatar Medical Journal. 2021. Vol. 2021, no. 2, pp.1-11.
https://search.emarefa.net/detail/BIM-1448217
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-11
Record ID
BIM-1448217