Chemical and pharmacological aspects of novel hetero MLB complexes derived from NO2 type Schiff base and N2 type 1,10-phenanthroline ligands

Abstract EN

A series of hetero ligand MLB complexes (1–5) were synthesised from tridentate NO2 type Schiff base [H2L: (E)-2-((2-hydroxy-4-methoxyphenyl)(phenyl)methyleneamino)benzoic acid; derived from 2-hydroxy-4-methoxybenzophenone and 2-aminobenzoic acid] and bidentate N2 type 1,10-phenanthroline (B: phen) ligands.

The structural characterization of the synthesised MLB complexes were carried out via analytical as well as various spectral studies.

Additionally, the low molar conductance values (Λm = 14–22 Ω−1 cm2 mol−1) imply that the complexes (1–5) are non-electrolytes.

The obtained results reinforce that stoichiometry of the mononuclear hetero ligand complexes can be represented as [M(II)-Schiff base(L)-phen(B)·H2O] and both H2L and (B) ligands can act as tri and bidentates respectively.

Moreover, both the ligands bind with metal(II) ions to build a stable six, six, five membered chelate rings with octahedral geometry.

The existing solvent water molecule is confirmed from thermal as well as vibrational analysis.

Their microcrystalline nature and uniform surface morphology were confirmed by both powder XRD and SEM studies.

3D molecular modeling and analysis of NiLB and CuLB complexes (3 and 4) were also studied.

Mn(II), Ni(II) and Cu(II) complexes (1, 3 and 4) strongly interact with DNA through intercalation binding with strong binding constant values.

The obtained Kapp values were 5.23, 4.98, 6.36, 7.21 and 4.86 × 105 mol−1 for MLB complexes (1–5) respectively and the negative Δ‡G values shown that all the complexes are strongly interact with DNA in a spontaneous manner.

Further, remarkable biological, antioxidant and DNA activities were remarkably exhibited by MnLB, NiLB and CuLB complexes.