Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates
Joint Authors
Yang, Song
Wang, Pei Yi
Zhu, Huai He
Zeng, Dan
Wang, Ming Wei
Wu, Yuan Yuan
Liu, Li Wei
Source
Journal of Saudi Chemical Society
Issue
Vol. 24, Issue 1 (31 Jan. 2020), pp.127-138, 12 p.
Publisher
Publication Date
2020-01-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Abstract EN
Plant microbial diseases caused global production constraints have become one of the most challenging events, thus urgently needing to be addressed nowadays.
To efficiently promote the discovery of promising antimicrobial surrogates, a type of 1,3,4-oxadiazole thioethers owning naturally bioactive thiazolium patterns was designed and fabricated.
Antibacterial screening results revealed that title compounds could significantly inhibit the growth of pathogens Xanthomonas oryzae pv.
oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv.
citri.
And the related antibacterial efficacy was elevated by approximately 386-, 16-, and 24-folds comparing those of mainly used commercial agents bismerthiazol and thiodiazole copper.
In vivo experiment suggested that A9 could manage rice bacterial blight with the corresponding curative and protection efficiencies of 48.01% and 50.55% at 200 μg/mL.
Moreover, SEM patterns and fluorescence spectra were performed to explore the possible antibacterial mechanism.
Preliminary antifungal bioassays revealed that these molecules paraded broad-spectrum inhibition effects against three tested fungal strains.
Considering the simple molecular skeleton and significant biological actions, title compounds can be further explored as potential antimicrobial surrogates for managing plant bacterial and fungal diseases.
American Psychological Association (APA)
Zhu, Huai He& Zeng, Dan& Wang, Ming Wei& Wang, Pei Yi& Wu, Yuan Yuan& Liu, Li Wei…[et al.]. 2020. Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates. Journal of Saudi Chemical Society،Vol. 24, no. 1, pp.127-138.
https://search.emarefa.net/detail/BIM-1450250
Modern Language Association (MLA)
Zhu, Huai He…[et al.]. Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates. Journal of Saudi Chemical Society Vol. 24, no. 1 (Jan. 2020), pp.127-138.
https://search.emarefa.net/detail/BIM-1450250
American Medical Association (AMA)
Zhu, Huai He& Zeng, Dan& Wang, Ming Wei& Wang, Pei Yi& Wu, Yuan Yuan& Liu, Li Wei…[et al.]. Integration of naturally bioactive thiazolium and 1,3,4-oxadiazole fragments in a single molecular architecture as prospective antimicrobial surrogates. Journal of Saudi Chemical Society. 2020. Vol. 24, no. 1, pp.127-138.
https://search.emarefa.net/detail/BIM-1450250
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 137-138
Record ID
BIM-1450250