تحضير و تشخيص و تقييم الفعالية البيولوجية و دراسة تأثير الليزر لمعقدات الكوبلت "II" من مزيج الليكاندات

Abstract EN

New cobalt (II) complexes with mixed ligands including [(2- oxime-4-hydrazone) pentane (L1H) and 2-chlorobenzaldehyde thiosemicarbazone (T1H), or 3,4-dimethoxy acetophenone thiosemicarbazone (T2H); glycine (GH) or metformin (mf)] have been prepared in both pH (6.5-7) and (9.5-10) using classical and microwave techniques.

The resulting complexes have been characterized using physio- chemical and spectral techniques.

The study suggested that the complexes have the general formulate: [Co (L1H) (TH) (BH)] (CH3COO) 2 at pH (6.5-7) and [Co (L1) (TH) (G)] or [Co(L1) (T)(mf)) at (9.5- 10), respectively {where TH= T1H or T2H; T= deprotonated T1H or T2H; L1H=L1=deprotonated; BH= GH or mf; G= deprotonated GH].

Hexacoordinated mononuclear complexes having distorted octahedral geometries have been investigated.

No laser effects have been observed on solid ligands and complexes indicating that the compounds are stable and not affected by He-Ne laser (wave length are = 600- 700 nm).

The biological activity of the ligands and complexes have been evaluated by agar plate diffusion technique against Echerichia coli, Klipsila pneumonia, Staphylococcus aureus and Pseudomonas aeruginosa.

Some compounds have been found to have antibacterial activity.