Prediction of potential mutation of chicken coronavirus into future human coronavirus based on spike s1 glycoprotein gene
Joint Authors
Barwary, Muwaffaq S.
Hasan, Shekhmous H.
Husayn, Shahrzad M.
Mustafa, Sarbast I.
Isa, Renas H.
Source
Issue
Vol. 24, Issue 2 العلوم الزراعية و البيطرية (31 Dec. 2021), pp.68-80, 13 p.
Publisher
Publication Date
2021-12-31
Country of Publication
Iraq
No. of Pages
13
Main Subjects
Abstract EN
The high mutation rates of the chicken coronavirus (IBV) cause economic threats to the poultry industry.
However, the most dangerous situation is the likelihood of changing its sequences into human coronavirus (COVID-19-like virus).
Therefore, in the present study we aimed to investigate the possibility of genetic mutation of IBV to COVID-19.
Thus, the sequences of Spike (SI) Glycoprotein genes of both IBV and COVID-19 were aligned, analyzed and calculated to predict the possible changes that could happen in the sequences of SI.
The results indicated that in the case of an independent function of probability of each cluster of SI sequences, the potential mutation rate in the sequences of IBV to be as COVID-19 was equal to 1.87E-96.
However, because the tendency for some sequence clusters of SI gene was low or equal to zero, it is unattainable to mutate the chicken IBV into COVID-19 sequence.
Furthermore, in case of the dependent function, the probability of assumed annual mutation to make IBV' infectious for human may reach up to around 50% after about 260 years.
As a conclusion, the mutating of chicken coronavirus into COVID-19-like virus is not impossible, but it might take a substantial period of time.
American Psychological Association (APA)
Hasan, Shekhmous H.& Husayn, Shahrzad M.& Mustafa, Sarbast I.& Isa, Renas H.& Barwary, Muwaffaq S.. 2021. Prediction of potential mutation of chicken coronavirus into future human coronavirus based on spike s1 glycoprotein gene. Journal of Dohuk University،Vol. 24, no. 2 العلوم الزراعية و البيطرية, pp.68-80.
https://search.emarefa.net/detail/BIM-1478741
Modern Language Association (MLA)
Hasan, Shekhmous H.…[et al.]. Prediction of potential mutation of chicken coronavirus into future human coronavirus based on spike s1 glycoprotein gene. Journal of Dohuk University Vol. 24, no. 2 Agriculture and Veterinary Sciences (2021), pp.68-80.
https://search.emarefa.net/detail/BIM-1478741
American Medical Association (AMA)
Hasan, Shekhmous H.& Husayn, Shahrzad M.& Mustafa, Sarbast I.& Isa, Renas H.& Barwary, Muwaffaq S.. Prediction of potential mutation of chicken coronavirus into future human coronavirus based on spike s1 glycoprotein gene. Journal of Dohuk University. 2021. Vol. 24, no. 2 العلوم الزراعية و البيطرية, pp.68-80.
https://search.emarefa.net/detail/BIM-1478741
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 78-80
Record ID
BIM-1478741