Silver nanoparticles attenuate inflammation aggravation in hepatocellular carcinoma in rats
Joint Authors
Rifat, M. M.
Muhammad, M. R.
Rafat, Amani I.
Hassan, Asma A.
Fathi, Shadiyah A.
Uthman, S. A.
Source
Arab Journal of Nuclear Sciences and Applications
Issue
Vol. 56, Issue 4 (31 Jul. 2023), pp.73-80, 8 p.
Publisher
The Egyptian Society of Nuclear Science and Applications
Publication Date
2023-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Using silver nanoparticles is a promising tactic in healthcare and cancer therapy, either alone or as an adjuvant in traditional chemotherapy.
also, using gamma radiation in nanoparticle preparation is simple, powerful, and environmentally friendly.
this study aimed to assess the impact of silver nanoparticles (AgNPs) prepared by gamma radiation (γ-radiation) on hepatocellular carcinoma (HCC) induced by diethyl-nitrosamine (DEN).
MTT cytotoxicity assay of AgNPs has been detected in vitro on Wi38 normal fibroblast and HepG2 hepatocellular carcinoma cell lines.
twenty-eight adult male albino rats were divided into four groups.
after HCC development, rats received (10µg / g b.
wt.
) of AgNPs, three times a week for four weeks liver enzymes were investigated.
TNF-α, TGF-β, and IL-1β inflammatory markers were detected.
also, the transcriptional factor (NF-κB) was calculated.
the obtained results confirmed the selective influence of AgNPs on the HCC cell line in a time and dose-dependent manner.
moreover, the role of AgNPs is documented in diminishing the inflammation accompanied by HCC development through decreased inflammatory markers and increased apoptosis.
American Psychological Association (APA)
Rifat, M. M.& Fathi, Shadiyah A.& Muhammad, M. R.& Uthman, S. A.& Rafat, Amani I.& Hassan, Asma A.. 2023. Silver nanoparticles attenuate inflammation aggravation in hepatocellular carcinoma in rats. Arab Journal of Nuclear Sciences and Applications،Vol. 56, no. 4, pp.73-80.
https://search.emarefa.net/detail/BIM-1485889
Modern Language Association (MLA)
Rifat, M. M.…[et al.]. Silver nanoparticles attenuate inflammation aggravation in hepatocellular carcinoma in rats. Arab Journal of Nuclear Sciences and Applications Vol. 56, no. 4 (Jul. 2023), pp.73-80.
https://search.emarefa.net/detail/BIM-1485889
American Medical Association (AMA)
Rifat, M. M.& Fathi, Shadiyah A.& Muhammad, M. R.& Uthman, S. A.& Rafat, Amani I.& Hassan, Asma A.. Silver nanoparticles attenuate inflammation aggravation in hepatocellular carcinoma in rats. Arab Journal of Nuclear Sciences and Applications. 2023. Vol. 56, no. 4, pp.73-80.
https://search.emarefa.net/detail/BIM-1485889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 78-80
Record ID
BIM-1485889