Measurement of alkaline phosphatase activity and calcium levels in Sudanese patients with breast cancer

Abstract EN

Breast cancer is the most common cancer affecting women in Sudan, it is characterized by metastatic pattern in liver and bone.

changes in serum levels of biochemical parameters especially alkaline phosphatase (ALP) may be valuable in diagnosis of breast cancer.

this study was conducted to detect alkaline phosphatase activity and calcium level in sudanese patients with breast cancer,who attended the radiation and isotope Center of Khartoum hospital.during the period from March-May 2015.

in this retrospective, case-controlled, hospital-based study; 40 female patients with breast cancer (aged 25-85 years), and 40 healthy female control (aged 25-85 years) were enrolled in the study.

a questionnaire containing demographic and clinical data was completed for every patient.

venous blood (2.5ml) was taken in a plane container from every volunteer.

samples for alkaline phosphatase and calcium were processed and analyzed using spectrophotometric method.

the present study showed that there was a highly significant increase in alkaline phosphatase activity in patients compared to control (P<0.01), whereas insignificant increase in calcium level in patients compared to healthy control (P>0.05).thus, it was concluded that analysis of serum alkaline phosphatase and calcium in patients with breast cancer may help in monitoring metastasis, and to follow up of treatment response.