Association between inflammatory cytokines and liver functions in rheumatoid arthritis patients

Joint Authors

Ismail, Ammar Muhammad
al-Tahir, Muhammad Abd al-Rahman
Salih, Kawthar Abd al-Jalil Muhammad
Muhammad, al-Hajj Nur al-Din
Babkir, Faysal Makki

Source

Sudan Medical Laboratory Journal

Issue

Vol. 8, Issue 1 (31 Dec. 2020), pp.45-52, 8 p.

Publisher

Omdurman Islamic University Faculty of Medical Laboratory

Publication Date

2020-12-31

Country of Publication

Sudan

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Background : rheumatoid arthritis (RA) associated with abnormal liver tests, and medications used for RA are often hepatotoxic.

Therefore, this study aims to investigate an association between pro inflammatory, ant iinflammatory cytokines and liver function tests in rheumatoid arthritis patients.

materials and methods : in a descriptive cross-sectional study, 88 RA patients were included, 84 were females and 4 were males, age ranged from 21 to 81 years old.

serum interleukin 10 (IL-10), interleukin 17 (IL-17), Osteopontin OPN and liver function tests were measured.

results : the frequency of RA is higher among adults >41 Years 72(81.8%) than young adults ≤41 Years 16(18.2%), RA is common in females 84(95.5%) than males 4(4.5%) approximately 21:1 fold.

young adults had higher abnormal IL-10 than adults RA patients (OR = 3.72, p-value 0.044).

abnormal IL-17 (OR= 5.67, p-value 0.034) were found to be increased in young adults RA patients.

No association observed between age and OPN.

No association between duration of disease and IL-10, IL-17 and OPN.

No association found between types of treatment and IL-10, IL-17 and OPN.

No association observed between IL-10, IL-17, OPN and liver parameters (AST, ALT, ALP, ALB, TP, and GGT).conclusion : in conclusion proinflammatory and antiinflammatory cytokines are not associated with liver functions as has been demonstrated in RA patients.

American Psychological Association (APA)

al-Tahir, Muhammad Abd al-Rahman& Salih, Kawthar Abd al-Jalil Muhammad& Muhammad, al-Hajj Nur al-Din& Babkir, Faysal Makki& Ismail, Ammar Muhammad. 2020. Association between inflammatory cytokines and liver functions in rheumatoid arthritis patients. Sudan Medical Laboratory Journal،Vol. 8, no. 1, pp.45-52.
https://search.emarefa.net/detail/BIM-1491208

Modern Language Association (MLA)

al-Tahir, Muhammad Abd al-Rahman…[et al.]. Association between inflammatory cytokines and liver functions in rheumatoid arthritis patients. Sudan Medical Laboratory Journal Vol. 8, no. 1 (2020), pp.45-52.
https://search.emarefa.net/detail/BIM-1491208

American Medical Association (AMA)

al-Tahir, Muhammad Abd al-Rahman& Salih, Kawthar Abd al-Jalil Muhammad& Muhammad, al-Hajj Nur al-Din& Babkir, Faysal Makki& Ismail, Ammar Muhammad. Association between inflammatory cytokines and liver functions in rheumatoid arthritis patients. Sudan Medical Laboratory Journal. 2020. Vol. 8, no. 1, pp.45-52.
https://search.emarefa.net/detail/BIM-1491208

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 50-52

Record ID

BIM-1491208