Neutrophil-to-lymphocyte ratio not associated with early diagnosed prostatic carcinoma patients

Abstract EN

Background : prostate cancer has become the most common malignancy among men in several developed countries especially Sudan.

The neutrophils lymphocytes ratio (NLR) was one of recent inflammatory biomarkers, nowadays was used as predictor and prognostic tools in different malignant disorders aim : this study was aimed to assess the neutrophils to lymphocytes ratio in early diagnosed prostatic carcinoma patients.

materials and methods : this study is descriptive case control study, was conducted at almoalim medical city (AMC) Khartoum, Sudan.

one hundred males, fifty were known prostatic cancer patients (early diagnosed) used as case group.

others fifty were normal healthy male matched the case group in age used as normal control group.

the complete blood count (CBC) was done from EDTA anticoagulated blood samples and NLR was calculated using automated Hematology analyzer SYSMEX NX-550, prostate specific antigen was estimated using (chemiluminescence) e411 Cobas, all laboratory tests were made under fully quality control procedures.

data was collected by using direct structured questionnaire.

data was analyzed by SPSS version 18 and the significant value was present when the P.

value less than 0.05.

result : this study showed that the neutrophils lymphocytes ratio (NLR) and absolute lymphocytes were insignificant different in the early diagnosed prostatic carcinoma patients compared with normal non prostate cancer with p value more than 0.05 while the absolute neutrophils was showed a statistically significant different between case and control with p value 0.03.

conclusion : this study concluded that the neutrophils lymphocytes ratio (NLR) may not applicable as predictor prognostic marker for the early diagnosed prostatic carcinoma patients.