The polymorphisms of epidermal growth factor-driven signaling and cancer pathogenesis
Joint Authors
Andronic, Octavian
Dugaesescu, Monica
Musat, Florentina
Source
Sudan Journal of Medical Sciences
Issue
Vol. 16, Issue 2 (30 Jun. 2021), pp.207-222, 16 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2021-06-30
Country of Publication
Sudan
No. of Pages
16
Main Subjects
Abstract EN
Background : epidermal growth factor (EGF) is a stimulating protein for cell proliferation and differentiation.
an amplification of its signaling pathway has been frequently reported in numerous malignant tumors.
Specific polymorphisms of the genes encoding proteins involved in this cellular pathway may constitute risk factors for carcinogenesis.
the aim of this study was to identify the most relevant polymorphisms of EGF and their signaling pathways and their relation to carcinogenesis.
methods : the study included 40 full-text articles published between January 2010 and May 2020, extracted from PubMed, scopus, web of science, and science direct databases in May 2020, using the following keywords: EGF OR epidermal growth factor AND polymorphism AND cancer OR neoplasia OR tumor.
results : We identified relevant polymorphisms of the EGF signaling pathway that were involved in the development and progression of hepatocellular carcinoma, esophageal cancer, gastric cancer, colorectal cancer, glioma, lung cancer, breast cancer, cervical cancer, and head and neck cancer.
Rs4444903 variants have been widely studied and the association with numerous tumors has been confirmed by multiple studies.
other frequently investigated polymorphisms are –191C/A and –216G>T.
conclusion : the polymorphisms of EGF signaling pathway have been widely studied in connection to various malignancies.
some predisposing variants are common in different forms of cancer.
these polymorphisms might be general risk factors for carcinogenesis.
American Psychological Association (APA)
Dugaesescu, Monica& Musat, Florentina& Andronic, Octavian. 2021. The polymorphisms of epidermal growth factor-driven signaling and cancer pathogenesis. Sudan Journal of Medical Sciences،Vol. 16, no. 2, pp.207-222.
https://search.emarefa.net/detail/BIM-1491572
Modern Language Association (MLA)
Dugaesescu, Monica…[et al.]. The polymorphisms of epidermal growth factor-driven signaling and cancer pathogenesis. Sudan Journal of Medical Sciences Vol. 16, no. 2 (2021), pp.207-222.
https://search.emarefa.net/detail/BIM-1491572
American Medical Association (AMA)
Dugaesescu, Monica& Musat, Florentina& Andronic, Octavian. The polymorphisms of epidermal growth factor-driven signaling and cancer pathogenesis. Sudan Journal of Medical Sciences. 2021. Vol. 16, no. 2, pp.207-222.
https://search.emarefa.net/detail/BIM-1491572
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 217-222
Record ID
BIM-1491572