Aerobic conditions application for C-N Coupling reaction catalyzed with Copper salt to form N-aryl biguanide derivative

Abstract EN

Ullman reaction has wide applications in the pharmaceutical industry.

One of its uses is C-N coupling between the halide aryl and alkyl amine.

In this study, we synthesize biguanide N-Aryl with Ullman reaction conditions.

The results show that the compound can be obtained using aerobic conditions with CuCl₂ as a catalyze, water and acetone as a reaction solvent, argenin as a Ligand.

The reaction yield was not so much.

The identification tests for the compound such as IR and LC-MS\MS confirmed its structure.

We recommend enhancing the reaction yield by studying different condition and to investigate the compound bioactivity as well.