Antioxidant vitamins are correlated with different aspects of phagocytic processes in healthy nigerians : benefits as supplements during antimicrobial treatment
Joint Authors
Arinola, Ganiyu Olatunbosun
Edem, Fabian Victory
Source
Sudan Journal of Medical Sciences
Issue
Vol. 15, Issue 3 (30 Sep. 2020), pp.223-234, 12 p.
Publisher
Omdurman Islamic University Faculty of Medicine
Publication Date
2020-09-30
Country of Publication
Sudan
No. of Pages
12
Main Subjects
Abstract EN
Background: Antioxidant vitamins are important for the immune system to function efficiently through several mechanisms.
However, according to several previous studies, individual step of leucocyte phagocytosis is not correlated with different antioxidant vitamins.
Methods: This study included 50 healthy Nigerians whose cellular phagocytic mechanism such as percentage leucocyte migration (%LM) and intracellular killing (%Nitroblue Tetrazolium Test) were determined by microscopy, neutrophil chemokines [plasma interleukin 8 (IL-8)] was determined using ELISA, and respiratory burst indices [plasma catalase (CAT), superoxide dismutase (SOD), myeloperoxidase (MPO), hydrogen peroxide (H2O2), and nitric oxide (NO)] were determined by spectrophotometry.
While the plasma antioxidant vitamins (Vitamins A, C, and E) were determined using HPLC, the phagocytic indices, chemokines, and respiratory burst indices were correlated with plasma antioxidant vitamins using Spearman’s Correlation analysis at α0.05.
Results: The results show that although among the healthy Nigerian adults, vitamin C was significantly and positively correlated with %NBT, it was negatively correlated with CAT activity.
Vitamin A showed a significantly positive correlation with SOD while Vitamin E showed a significantly negative correlation with MPO.
Conclusions: These findings suggest that antioxidant vitamins affect different stages of phagocytosis.
It is advisable to use a combination of antioxidant vitamins as supplements with recommended treatment strategies against intracellular micro-organisms or inflammatory diseases.
American Psychological Association (APA)
Arinola, Ganiyu Olatunbosun& Edem, Fabian Victory. 2020. Antioxidant vitamins are correlated with different aspects of phagocytic processes in healthy nigerians : benefits as supplements during antimicrobial treatment. Sudan Journal of Medical Sciences،Vol. 15, no. 3, pp.223-234.
https://search.emarefa.net/detail/BIM-1492677
Modern Language Association (MLA)
Arinola, Ganiyu Olatunbosun& Edem, Fabian Victory. Antioxidant vitamins are correlated with different aspects of phagocytic processes in healthy nigerians : benefits as supplements during antimicrobial treatment. Sudan Journal of Medical Sciences Vol. 15, no. 3 (2020), pp.223-234.
https://search.emarefa.net/detail/BIM-1492677
American Medical Association (AMA)
Arinola, Ganiyu Olatunbosun& Edem, Fabian Victory. Antioxidant vitamins are correlated with different aspects of phagocytic processes in healthy nigerians : benefits as supplements during antimicrobial treatment. Sudan Journal of Medical Sciences. 2020. Vol. 15, no. 3, pp.223-234.
https://search.emarefa.net/detail/BIM-1492677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 231-234
Record ID
BIM-1492677