Efficiency and safety of desferioxamine chelation therapy in paediatric patients with transfusion-dependent anaemia : experience of two centers from Sudan
Joint Authors
al-Sad, Atif.
Masud, Samah.
al-Hasan, Uthman.
Zulfu, Azzah.
Source
al-Kindy College Medical Journal
Issue
Vol. 18, Issue 2 (31 Aug. 2022), pp.132-135, 4 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2022-08-31
Country of Publication
Iraq
No. of Pages
4
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Background: Repeated blood transfusion is the main therapeutic option for transfusiondependent anaemias with consequent iron overload and organ damage .Therefore iron chelating agents are important protective measures for these patients.
The aim of this study was to investigate the efficiency and safety of Desferroxamine in paediatrics population subjected to iron overload as a consequence of repeated transfusion in a group of Sudanese children Subjects & Methods: This was a descriptive cross-sectional hospital based study.
Conducted in two main paediatric reference hospitals in, Sudan.
Within the period between November 2017 and April 2018 (6 months duration).
The two centres were JaafarI bn- Oaf hospital and Albulk hospital.
The study population included all patients of transfusion dependent anaemia who received desferrioxamine within the study period.
Hundred patients were enrolled in the study.
The study variables were demographic data, number of blood transfusions , serum ferritin pre and post blood transfusion and treatment of desferrioxamin Results: Sixty percent (60%) of the studied cases were males and 40% were females ,46% were thalassemic, 46% were sicklers, 5% aplastic anemia and 3% with red cell aplasia .The mean serum ferritin level before starting desferoxamine was 2.14 and after dessferoxamine was 2.48, P –value was highly significant.
The most common side effect encountered was skin rash (36%) Conclusion: This study revealed some features of safety and efficiency of desferoxamine therapy in Sudanese paediatrics population affected by transfusion-dependent anemia.
More studies are needed to describe this important health problem
American Psychological Association (APA)
al-Sad, Atif.& Masud, Samah.& al-Hasan, Uthman.& Zulfu, Azzah.. 2022. Efficiency and safety of desferioxamine chelation therapy in paediatric patients with transfusion-dependent anaemia : experience of two centers from Sudan. al-Kindy College Medical Journal،Vol. 18, no. 2, pp.132-135.
https://search.emarefa.net/detail/BIM-1493214
Modern Language Association (MLA)
al-Sad, Atif.…[et al.]. Efficiency and safety of desferioxamine chelation therapy in paediatric patients with transfusion-dependent anaemia : experience of two centers from Sudan. al-Kindy College Medical Journal Vol. 18, no. 2 (Aug. 2022), pp.132-135.
https://search.emarefa.net/detail/BIM-1493214
American Medical Association (AMA)
al-Sad, Atif.& Masud, Samah.& al-Hasan, Uthman.& Zulfu, Azzah.. Efficiency and safety of desferioxamine chelation therapy in paediatric patients with transfusion-dependent anaemia : experience of two centers from Sudan. al-Kindy College Medical Journal. 2022. Vol. 18, no. 2, pp.132-135.
https://search.emarefa.net/detail/BIM-1493214
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 134-135
Record ID
BIM-1493214