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Metformin as an adjuvant treatment in non-diabetic metastatic breast cancer
Joint Authors
Ahmad, Hassan
Salah, Hajir
Salah, Hajir
Rabi, Huda
al-Birry, Ahmad A.
Source
Issue
Vol. 43, Issue 2 (30 Jun. 2021), pp.477-481, 5 p.
Publisher
King Hamad University Hospital
Publication Date
2021-06-30
Country of Publication
Bahrain
No. of Pages
5
Main Subjects
Abstract EN
Mounting evidence suggests that metformin halts cancer spread and acts as an antimetastatic drug.
Patients and Methods : Fifty women diagnosed with stage IV breast cancer were allocated randomly into two groups.
The control group received chemotherapy and the metformin group received metformin plus chemotherapy for 3 months.
Main outcome included measuring changes in tumors using Response Evaluation Criteria in Solid Tumors (RECIST) to evaluate disease progression before and after 3 months, whereas secondary outcomes included, overall survival (OS) and progression free survival (PFS).
Results : The control group had a significantly worse RECIST response rate than the metformin group.
The metformin group had a slightly longer OS and higher PFS than the control group, but this difference was not statistically significant.
Hazards of mortality and disease progression were reduced with metformin use.
Conclusion : Metformin use significantly improved the radiologic response rate in nondiabetic patients with metastatic breast cancer but did not significantly prolonged OS or PFS.
Our results suggest that randomized clinical trials in patients with metastatic breast cancer are warranted.
Clinical Trial.gov ID : NCT04143282
American Psychological Association (APA)
Salah, Hajir& Rabi, Huda& Ahmad, Hassan& al-Birry, Ahmad A.& Salah, Hajir. 2021. Metformin as an adjuvant treatment in non-diabetic metastatic breast cancer. Bahrain Medical Bulletin،Vol. 43, no. 2, pp.477-481.
https://search.emarefa.net/detail/BIM-1493221
Modern Language Association (MLA)
Ahmad, Hassan…[et al.]. Metformin as an adjuvant treatment in non-diabetic metastatic breast cancer. Bahrain Medical Bulletin Vol. 43, no. 2 (Jun. 2021), pp.477-481.
https://search.emarefa.net/detail/BIM-1493221
American Medical Association (AMA)
Salah, Hajir& Rabi, Huda& Ahmad, Hassan& al-Birry, Ahmad A.& Salah, Hajir. Metformin as an adjuvant treatment in non-diabetic metastatic breast cancer. Bahrain Medical Bulletin. 2021. Vol. 43, no. 2, pp.477-481.
https://search.emarefa.net/detail/BIM-1493221
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1493221