Spectrophotometric determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as coupling reagent
Joint Authors
Abd al-Razzaq, Thuqa M.
Sultan, Sad H.
Source
College of Basic Education Researches Journal
Issue
Vol. 19, Issue 1 (31 Mar. 2023), pp.741-752, 12 p.
Publisher
University of Mosul College of Basic Education
Publication Date
2023-03-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Abstract EN
A Sensitive, rapid and selective spectrophotometric method was developed for the determination of sulfacetamide sodium in an aqueous solution.
The method is based on the oxidative coupling reaction with 2,4-dinitophenylhydrazine in the basic medium in the presence of potassium periodate to produce an intense orange colour product, soluble in water, stable and gives maximum absorbance at 484 nm.
The linearity of Beer's law was in the range of 2.5-75 μg/ml of sulfacetamide.
The molar absorptivity, Sandellʼs sensitivity, and detection limit were 3202.92 L/mol.cm, 0.07936 µg/cm2 and 0.50476 μg/ml respectively.
This method is applied successfully to the determination of sulfacetamide in pharmaceutical preparation (eye drops and ointment).
American Psychological Association (APA)
Abd al-Razzaq, Thuqa M.& Sultan, Sad H.. 2023. Spectrophotometric determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as coupling reagent. College of Basic Education Researches Journal،Vol. 19, no. 1, pp.741-752.
https://search.emarefa.net/detail/BIM-1493475
Modern Language Association (MLA)
Abd al-Razzaq, Thuqa M.& Sultan, Sad H.. Spectrophotometric determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as coupling reagent. College of Basic Education Researches Journal Vol. 19, no. 1 (2023), pp.741-752.
https://search.emarefa.net/detail/BIM-1493475
American Medical Association (AMA)
Abd al-Razzaq, Thuqa M.& Sultan, Sad H.. Spectrophotometric determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as coupling reagent. College of Basic Education Researches Journal. 2023. Vol. 19, no. 1, pp.741-752.
https://search.emarefa.net/detail/BIM-1493475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 750-752
Record ID
BIM-1493475