Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives
Joint Authors
Taha, Muhammad
Arshia
Khan, Khalid Muhammad
Kanwal
Khan, Firdaws Alam
Source
Journal of Saudi Chemical Society
Issue
Vol. 23, Issue 7 (30 Nov. 2019), pp.775-780, 6 p.
Publisher
Publication Date
2019-11-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Abstract EN
Derivatives (1-15) of steroidal and indole class were synthesized using different strate gies.
These compounds were characterized by 'H NMR spectroscopy and EI-MS, respectively.
The synthetic derivatives were examined for their cytotoxic effects on human adenocarcinoma cells (HCT-116) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and morphometric analysis.
The cytotoxic effects of all the compounds were observed after 48 h treat ment and it was found that out of fifteen, four compounds 1, 2, 3, and 14 showed inhibitory action on the cancer cells.
We have calculated the IC50 values for compounds 1, 2, 3, and 14 which were 22.50 µg/mL, 55.65 µg/mL, 21.35 µg/mL and 58.50 µg/mL, respectively.
The compounds 3 (IC so = 21.35 µg/mL) and 1 (ICso = 22.50 µg/mL) showed highest inhibitory activities as com pared to compounds 2 (IC s0= 55.65 µg/mL) and 14 (IC50 58.50 µg/mL).
These results suggested that steroidal thiazole and indole derivatives are potent lead molecules having strong anti-cancer proliferative capabilities.
American Psychological Association (APA)
shamim, Furayhah& Kanwal& Khan, Firdaws Alam& Taha, Muhammad& Khan, Khalid Muhammad& Arshia. 2019. Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives. Journal of Saudi Chemical Society،Vol. 23, no. 7, pp.775-780.
https://search.emarefa.net/detail/BIM-1493834
Modern Language Association (MLA)
shamim, Furayhah…[et al.]. Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives. Journal of Saudi Chemical Society Vol. 23, no. 7 (Nov. 2019), pp.775-780.
https://search.emarefa.net/detail/BIM-1493834
American Medical Association (AMA)
shamim, Furayhah& Kanwal& Khan, Firdaws Alam& Taha, Muhammad& Khan, Khalid Muhammad& Arshia. Synthesis and in vitro anti-proliferative capabilities of steroidal thiazole and indole derivatives. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 7, pp.775-780.
https://search.emarefa.net/detail/BIM-1493834
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 779-780
Record ID
BIM-1493834