Synthesis, characterization, electrochemical behavior and antioxidant activity of new copper(II)‎ coordination compounds with curcumin derivatives

Abstract EN

Five new copper(II) coordination compounds were prepared by template synthesis, using curcumin, 2-hydrazinobenzothiazole and metal salt (copper chloride, bromide, acetate and nitrate) in 1 : 2 : 1 and 1 : 2 : 2 molar ratio.

The complexes were characterized by elemental and thermogravimet ric analysis, IR, UV-Vis and mass spectroscopic methods and cyclic voltammetric studies.

On the basis of physico-chemical measurements the following formulae have been assigned to the com plexes : [Cu(H₂L)(H₂O)₂]Cl₂-H₂O.

[CuL] H₂O, [Cu(H₂L)(H₂O)Br]Br-5H₂O, [Cu₂L(H₂O)4](NO3)2 2H₂O and [Cu₂(H₂L)(NO3)4] H₂O, where H₂L is the hydrazone ligand formed in the reaction conditions.

Metal complexes were tested for antioxidant activity by photochemiluminescence and this activity was quantified by comparison with TROLOXⓇ®, as standard.

The results show that all complexes are more potent antioxidant agents than curcumin.