CuSO4 sodium ascorbate catalysed synthesis of benzosuberone and 1,2,3-triazole conjugates : design, synthesis and in vitro anti-proliferative activity

Abstract EN

A novel series of conjugates of benzosuberone and 1,2,3-triazole i.e.

3-(4-phenyl-1H-1, 2,3-triazol-1-yl)propyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulene-8-carboxylic acids (8a-j) were synthesized in good to excellent yields catalysed by CuSO4 under milder reaction con ditions and evaluated for their anti-proliferative activity.

The structural elucidation of the prepared compounds was carried out using IR, 'H NMR, ¹³C NMR and Mass spectral analysis.

The newly synthesized derivatives (8a-j) were evaluated for their anti-proliferative activity against four human cell lines and the novel derivatives showed moderate to excellent activity.

The obtained results sug gest that these compounds can be considered as new hits for anti-proliferative drug development programme and further SAR studies can help obtain better anticancer agents.