Two sisters were diagnosed with childhood systemic lupus erythematous

Abstract EN

We are herein reporting two female siblings with childhood-onset Systemic Lupus Erythematosus (SLE).

The children were diagnosed as having SLE in reverse birth order at ages 2 and 6 years.

Younger sister's initial symptoms were serositis, proteinuria, and hemolytic anemia with laboratory findings of hypocomplementemia and positive ANA/anti-dsDNA antibody.

After 18 months, the older sister presented with high-grade fever, arthralgia proteinuria, oral mucous ulcer, butterfly rash, and positive ANA/anti-dsDNA antibody.