تحري بلورة تشاركية للفلوربيبروفن مع النيكوتين أميد و حمض الأديبيك باستخدام طريقة تبخير المذيب البطيئة و السريعة

Abstract EN

The research aims to investigate obtaining co-crystals of flurbiprofen (FLU), which is an NSAID, by studying the thermal behavior, infrared spectroscopy and the dissolution rate of the produced crystals.

The FLU was crystallized with nicotine amide (NCT) and adipic acid (ADP) as two components of the coformer by slow and fast solvent evaporation methods, then the thermal behavior was compared through differential thermal scanning (DSC).

Infrared spectroscopy (FTIR) and the dissolution rate of (FLU) with (FLU) released from the physical mixture consisting of (FLU) with each of (coformers) separately in a ratio of (1: 1 mol) and with (FLU) released from the crystallized mixture.

The results showed the formation of a co-crystal between (FLU) and (NCT), where a sharp endothermic peak appeared different from the peaks of the physical mixture and the peaks of the starting materials and (FTIR) showed a decrease in the intensity of vibration of the amine group in (NCT) as well as in the carbonyl group in (FLU).

The dissolution rate of (FLU) increased significantly compared with (FLU) released from the physical mixture and with (FLU) released from the corresponding mixture crystallized, statistically significant (P <0.05).

While the results of the comparison showed the inability of (FLU) to form a co-crystal with (ADP).