Investigation of Terminalia arjuna as potential IL-4 and IL-13 modulator for the prevention of autoimmune diabetes : a pharmacoinformatics-based study
Joint Authors
Khalid, Muhammad
Unnisa, Aziz
Ahmad, Sahim
Jandrajupalli, Suresh Babu
Yunus, Karim M.
Abu Bakr, Sali Hasan
Chandolu, Swarnalatha
Lakshmi Sudeepthi, N.
Source
Issue
Vol. 50, Issue 1 A (31 Jan. 2023), pp.1-14, 14 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2023-01-31
Country of Publication
Kuwait
No. of Pages
14
Main Subjects
Abstract EN
Cytokines are proteins that play a critical role in the development, maturation, and functional activities of immune cells.
For the first time, we have investigated the potential role of Terminalia arjuna as IL-4 and IL-13 modulators for preventing T1DM, i.e., autoimmune diabetes.
It has been well documented that the stimulation of IL-4 and IL-13 can regulate the level of type 2 cytokines which can be maintained with the level of type 1 cytokines.
In the present study, gallic acid, arjunolic acid, luteolin, ellagic acid, and arjunone were investigated for their potential modulating activity of IL-4 and IL-13.
The active amino acid residues identified for IL-4 are VAL51, HIS58, ASP87, THR30, GLN54, THR63, ARG64, LYS84, and GLU60.
The active amino acid residues identified for IL-13 are H: GLU46, H: TRP47, H: GLN61, L: PHE98, L: VAL97, L: GLU162, L: THR163, H: ARG105, L: GLN38, L: ASP85, H: GLY42, L: GLY41, H: PRO41, H: TRP47, and L: PHE98.
The phytoconstituents demonstrated better modulating activity towards IL-13 than IL-4.
Luteolin displayed better potential for both IL-4 and IL-13, and therefore we concluded that it could be used to modulate the activity of IL-4 and IL-13 for the prevention of autoimmune diabetes.
American Psychological Association (APA)
Unnisa, Aziz& Ahmad, Sahim& Jandrajupalli, Suresh Babu& Yunus, Karim M.& Abu Bakr, Sali Hasan& Chandolu, Swarnalatha…[et al.]. 2023. Investigation of Terminalia arjuna as potential IL-4 and IL-13 modulator for the prevention of autoimmune diabetes : a pharmacoinformatics-based study. Kuwait Journal of Science،Vol. 50, no. 1 A, pp.1-14.
https://search.emarefa.net/detail/BIM-1499951
Modern Language Association (MLA)
Unnisa, Aziz…[et al.]. Investigation of Terminalia arjuna as potential IL-4 and IL-13 modulator for the prevention of autoimmune diabetes : a pharmacoinformatics-based study. Kuwait Journal of Science Vol. 50, no. 1 A (Jan. 2023), pp.1-14.
https://search.emarefa.net/detail/BIM-1499951
American Medical Association (AMA)
Unnisa, Aziz& Ahmad, Sahim& Jandrajupalli, Suresh Babu& Yunus, Karim M.& Abu Bakr, Sali Hasan& Chandolu, Swarnalatha…[et al.]. Investigation of Terminalia arjuna as potential IL-4 and IL-13 modulator for the prevention of autoimmune diabetes : a pharmacoinformatics-based study. Kuwait Journal of Science. 2023. Vol. 50, no. 1 A, pp.1-14.
https://search.emarefa.net/detail/BIM-1499951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-14
Record ID
BIM-1499951