Involvement of miR-3648 mediated APC2 dysregulation in early onset and breast cancer progression
Joint Authors
Batul, Mehwish
Qadir, Javeria
Shan, Misbah
Li, Feiya
Malik, Faraz A.
Awan, Hassan M.
Source
Issue
Vol. 50, Issue 1 A (31 Jan. 2023), pp.1-12, 12 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2023-01-31
Country of Publication
Kuwait
No. of Pages
12
Main Subjects
Abstract EN
Multiple cancers arise due to aberrations in the Wnt signaling pathway.
Several miRNAs modulate the integral components of the Wnt signaling pathway.
miR-3648 is a human-specific miRNAs that is of particular interest due to its minimum off-targeting.
In this study, we investigate the expression of miR-3648 and APC2 in breast cancer patients of Pakistan.
Possible association of miR-3648 and APC2 expression with clinico-pathological features and breast cancer subtypes was observed in tissue samples by means of quantitative real time PCR.
Our results showed that miR-3648 is relatively downregulated in Luminal A subtype, with corresponding upregulation of APC2 in these patients.
Moreover, the transcript levels of both miR-3648 and APC2 are inversely regulated in breast cancer affected women who presented with early disease onset, pre-menopause, low tumor grade, early clinical stage, absence of nodal invasion and metastasis, therefore, affirming molecular interplay of these molecules in breast cancer development and progression.
American Psychological Association (APA)
Batul, Mehwish& Qadir, Javeria& Shan, Misbah& Li, Feiya& Malik, Faraz A.& Awan, Hassan M.. 2023. Involvement of miR-3648 mediated APC2 dysregulation in early onset and breast cancer progression. Kuwait Journal of Science،Vol. 50, no. 1 A, pp.1-12.
https://search.emarefa.net/detail/BIM-1499961
Modern Language Association (MLA)
Batul, Mehwish…[et al.]. Involvement of miR-3648 mediated APC2 dysregulation in early onset and breast cancer progression. Kuwait Journal of Science Vol. 50, no. 1 A (Jan. 2023), pp.1-12.
https://search.emarefa.net/detail/BIM-1499961
American Medical Association (AMA)
Batul, Mehwish& Qadir, Javeria& Shan, Misbah& Li, Feiya& Malik, Faraz A.& Awan, Hassan M.. Involvement of miR-3648 mediated APC2 dysregulation in early onset and breast cancer progression. Kuwait Journal of Science. 2023. Vol. 50, no. 1 A, pp.1-12.
https://search.emarefa.net/detail/BIM-1499961
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 10-12
Record ID
BIM-1499961