Suppression of Fas expression in the hypertensive placental histology of rats given Nano herbal of Rhodomyrtus tomentosa leaves
Joint Authors
Situmorang, Putri Cahaya
Syahputra, Rony A.
Simanullang, Rostime H.
Source
Issue
Vol. 50, Issue 1 A (31 Jan. 2023), pp.1-16, 16 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2023-01-31
Country of Publication
Kuwait
No. of Pages
16
Main Subjects
Abstract EN
High blood pressure during pregnancy can signal a high-risk pregnancy and result in difficulties.
The expression of Fas is critical for maintaining hypertensive immunity.
Fas is prevalent in the trophoblast, which enhances maternal-derived apoptosis.
Because it contains acylphloroglucinol, flavonoids, tannins, and triterpenes, Rhodomyrtus tomentosa (haramonting) is commonly used in traditional Indonesian medicine to treat high blood pressure.
The goal was to determine and investigate the role of haramonting in lowering Fas expression in hypertensive rats' placental histopathology.
The rats were confirmed to be pregnant were divided into five treatments: (a) normal pregnant rats (control), (b) hypertensive rats (c) hypertensive rats + 100mg/KgBW NRT, (d) hypertensive rats + 200mg/KgBW NRT, and (e) hypertensive rats + 400mg/KgBW NRT.
On gestation day 20, pregnant rats were euthanized under ketamine anaesthesia.
ELISA was used to examine the expression of the HSP family.
Immunohistochemistry was used to assess Fas expression.
In hypertensive rats, NRT can lower systolic and diastolic blood pressure (P<0.01), and haramonting can improve placental efficiency and restore birth weight.
In hypertensive rats, the higher the dose of NRT, the higher the levels of HSP27, HSP70, and HSP90.
In placental histology, NRT suppresses Fas expression as anti-apoptotic in trophoblast cells.
Because NRT is high in antioxidants and protects cells from hypoxia and dehydration, it suppresses Fas activity in the labyrinthine zone, basal zone, and Yolk Sac.
American Psychological Association (APA)
Situmorang, Putri Cahaya& Syahputra, Rony A.& Simanullang, Rostime H.. 2023. Suppression of Fas expression in the hypertensive placental histology of rats given Nano herbal of Rhodomyrtus tomentosa leaves. Kuwait Journal of Science،Vol. 50, no. 1 A, pp.1-16.
https://search.emarefa.net/detail/BIM-1499988
Modern Language Association (MLA)
Situmorang, Putri Cahaya…[et al.]. Suppression of Fas expression in the hypertensive placental histology of rats given Nano herbal of Rhodomyrtus tomentosa leaves. Kuwait Journal of Science Vol. 50, no. 1 A (Jan. 2023), pp.1-16.
https://search.emarefa.net/detail/BIM-1499988
American Medical Association (AMA)
Situmorang, Putri Cahaya& Syahputra, Rony A.& Simanullang, Rostime H.. Suppression of Fas expression in the hypertensive placental histology of rats given Nano herbal of Rhodomyrtus tomentosa leaves. Kuwait Journal of Science. 2023. Vol. 50, no. 1 A, pp.1-16.
https://search.emarefa.net/detail/BIM-1499988
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 13-16
Record ID
BIM-1499988