Hydrazone bimetallic complex : synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA
Joint Authors
Ali, Mayadah S.
Kuraijam, Dhanachandra
Karnik, Sadashiva
Jaragh al-Hadad, Layla A.
Source
Issue
Vol. 50, Issue 3 A (31 Jul. 2023), pp.1-17, 17 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2023-07-31
Country of Publication
Kuwait
No. of Pages
17
Main Subjects
Abstract EN
Manganese complex of (N'E,N³E)-N",N"-bis(2-hydroxybenzylidene)isophthalo-hydrazide [H4L] was designed, spectroscopically analyzed, and confirmed via GC-MS, FTIR, CHNS, UV-VIS, magnetic susceptibility measurements, and molar electric conductivity.
the data confirmed the formation of ligand H+L and [Mn2(H₂L)CIJCI.2H₂O complex.
ligand H4L acts as a bi-negative hexadentate and tetra-negative hexadentate coordinating through two amide carbonyl, two azomethine, and two deprotonated OH groups.
the magnetic and spectral data proposed a square planar and a tetrahedral structure.
the TGA data confirmed the final metal oxide form for the Mn ligand complex.
additionally, an in-vitro assessment of the ligand H4L confirmed its ability to control cancer cell proliferation in both breast (MCF7) and lung (A549) cancer cell lines while the mn ligand complex possessed an anticancer effect in both cancer cells at the nano-molar level.
further, the in silico data showed four hydrogen bond interactions of the ligand with G-quadruplex DNA.
this strengthens our hypothesis that the hydrazone complex acts as an anticancer agent by targeting the G-quadruplex DNA.
American Psychological Association (APA)
Ali, Mayadah S.& Kuraijam, Dhanachandra& Karnik, Sadashiva& Jaragh al-Hadad, Layla A.. 2023. Hydrazone bimetallic complex : synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA. Kuwait Journal of Science،Vol. 50, no. 3 A, pp.1-17.
https://search.emarefa.net/detail/BIM-1501355
Modern Language Association (MLA)
Ali, Mayadah S.…[et al.]. Hydrazone bimetallic complex : synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA. Kuwait Journal of Science Vol. 50, no. 3 A (Jul. 2023), pp.1-17.
https://search.emarefa.net/detail/BIM-1501355
American Medical Association (AMA)
Ali, Mayadah S.& Kuraijam, Dhanachandra& Karnik, Sadashiva& Jaragh al-Hadad, Layla A.. Hydrazone bimetallic complex : synthesis, characterization, in silico and biological evaluation targeting breast and lung cancer cells’ G-quadruplex DNA. Kuwait Journal of Science. 2023. Vol. 50, no. 3 A, pp.1-17.
https://search.emarefa.net/detail/BIM-1501355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 12-17
Record ID
BIM-1501355